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    Cdk14 cyclin-dependent kinase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdk14provided by RGD
    Official Full Name
    cyclin-dependent kinase 14provided by RGD
    Primary source
    RGD:1305544
    See related
    EnsemblRapid:ENSRNOG00000007151 AllianceGenome:RGD:1305544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pftk1
    Summary
    Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; regulation of canonical Wnt signaling pathway; and regulation of cell cycle phase transition. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytosol and nucleus. Orthologous to human CDK14 (cyclin dependent kinase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 211.8), Lung (RPKM 200.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk14 in Genome Data Viewer
    Location:
    4q13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (29619237..30213651)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (28666416..29258865)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (25825567..26419443)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350663 Neighboring gene claudin 12 Neighboring gene PTTG1IP family member 2 Neighboring gene ribosomal protein S15a, pseudogene 6 Neighboring gene spermatogenesis associated glutamate (E)-rich protein 4C like 3 Neighboring gene uncharacterized LOC120102226 Neighboring gene frizzled class receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Serine/threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway. Yang HJ, et al. J Mol Neurosci, 2015 Apr. PMID 25355490
    2. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Parmasad JA, et al. Cell Death Dis, 2024 Apr 4. PMID 38575601, Free PMC Article
    3. A novel cdc2-related protein kinase expressed in the nervous system. Lazzaro MA, et al. J Neurochem, 1997 Jul. PMID 9202329
    4. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. Jiang M, et al. FEBS Lett, 2009 Jul 7. PMID 19524571
    5. Cell cycle control of wnt receptor activation. Davidson G, et al. Dev Cell, 2009 Dec. PMID 20059949

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
      Title: Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
    2. PFTK1 expression is markedly decreased during oligodendrocyte differentiation. PFTK1 overexpression suppresses oligodendrocyte differentiation in vitro.
      Title: Serine/threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 14
    Names
    PFTAIRE protein kinase 1
    cell division protein kinase 14
    NP_001382511.1
    NP_001382512.1
    NP_001382513.1
    XP_038963685.1
    XP_063142301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395582.1 → NP_001382511.1  cyclin-dependent kinase 14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6A7V5, D3ZSZ0
      Related
      ENSRNOP00000100241.1, ENSRNOT00000170629.1

    2. NM_001395583.1 → NP_001382512.1  cyclin-dependent kinase 14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6A7V5, D3ZSZ0

    3. NM_001395584.1 → NP_001382513.1  cyclin-dependent kinase 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D3ZSZ0
      Related
      ENSRNOP00000087492.2, ENSRNOT00000116950.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      29619237..30213651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107757.2 → XP_038963685.1  cyclin-dependent kinase 14 isoform X1

      UniProtKB/TrEMBL
      D3ZSZ0

    2. XM_063286231.1 → XP_063142301.1  cyclin-dependent kinase 14 isoform X1

      UniProtKB/TrEMBL
      D3ZSZ0
      Related
      ENSRNOP00000082191.2, ENSRNOT00000094279.2

    RNA

    1. XR_010065656.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108617.1: Suppressed sequence

      Description
      NM_001108617.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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