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    Snx2 sorting nexin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291464, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Snx2provided by RGD
    Official Full Name
    sorting nexin 2provided by RGD
    Primary source
    RGD:1310291
    See related
    EnsemblRapid:ENSRNOG00000017832 AllianceGenome:RGD:1310291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity; protein dimerization activity; and signaling receptor binding activity. Predicted to be involved in early endosome to Golgi transport and lamellipodium morphogenesis. Predicted to be located in lysosome and membrane. Predicted to be part of retromer, tubulation complex. Predicted to be active in endosome membrane. Orthologous to human SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 497.2), Spleen (RPKM 380.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx2 in Genome Data Viewer
    Location:
    18q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (48800594..48842158)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (46602223..46643870)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (48132386..48173974)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483021 Neighboring gene aminomethyltransferase, pseudogene 1 Neighboring gene sorting nexin 24 Neighboring gene peptidylprolyl isomerase C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin. Lieu ZZ, et al. Eur J Cell Biol, 2010 May. PMID 20138391
    2. A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Prosser DC, et al. Traffic, 2010 Oct. PMID 20604901
    3. SNX26, a GTPase-activating protein for Cdc42, interacts with PSD-95 protein and is involved in activity-dependent dendritic spine formation in mature neurons. Kim Y, et al. J Biol Chem, 2013 Oct 11. PMID 24003235, Free PMC Article
    4. Determinants of the endosomal localization of sorting nexin 1. Zhong Q, et al. Mol Biol Cell, 2005 Apr. PMID 15673616, Free PMC Article
    5. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Haft CR, et al. Mol Biol Cell, 2000 Dec. PMID 11102511, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leptin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in early endosome to Golgi transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer, tubulation complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106135.2 → NP_001099605.2  sorting nexin-2

      See identical proteins and their annotated locations for NP_001099605.2

      Status: VALIDATED

      Source sequence(s)
      AI146078, CB557295, CO565239, CO567837, DV723418
      UniProtKB/TrEMBL
      A0A8I6A678, B2RYP4
      Related
      ENSRNOP00000092031.2, ENSRNOT00000096252.2
      Conserved Domains (4) summary
      cd07282
      Location:142 → 265
      PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
      COG5391
      Location:51 → 509
      COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]
      pfam03700
      Location:49 → 112
      Sorting_nexin; Sorting nexin, N-terminal domain
      cl12013
      Location:283 → 516
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      48800594..48842158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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