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    Arhgap8 Rho GTPase activating protein 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300115, updated on 27-Nov-2024

    Summary

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    Symbol
    Arhgap8provided by RGD
    Full Name
    Rho GTPase activating protein 8provided by RGD
    Primary source
    RGD:1303143
    See related
    EnsemblRapid:ENSRNOG00000033570 AllianceGenome:RGD:1303143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of endocytic recycling; positive regulation of ERK1 and ERK2 cascade; and small GTPase-mediated signal transduction. Predicted to act upstream of or within actin cytoskeleton organization and positive regulation of cell migration. Predicted to be active in cytoplasm. Orthologous to human ARHGAP8 (Rho GTPase activating protein 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 70.7), Lung (RPKM 64.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap8 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (117723512..117782031)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (115842223..115902094)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (125732300..125797149, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene proline rich 5 Neighboring gene PHD finger protein 21B Neighboring gene nucleoporin 50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation. Ravichandran A, et al. Mol Biol Cell, 2013 Jan. PMID 23155002, Free PMC Article
    2. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Wang L, et al. Proc Natl Acad Sci U S A, 2007 Jan 23. PMID 17227869, Free PMC Article
    3. Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration. Pan CQ, et al. J Cell Sci, 2010 Mar 15. PMID 20179103
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unique role of BPGAP1 as a dual regulator for Ras and Rho signaling in cell morphogenesis and differentiation.
      Title: SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94058

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004242.1 → NP_001004242.1  rho GTPase-activating protein 8

      See identical proteins and their annotated locations for NP_001004242.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079089
      UniProtKB/TrEMBL
      Q6AYD8
      Related
      ENSRNOP00000017420.4, ENSRNOT00000017420.7
      Conserved Domains (2) summary
      cd00170
      Location:12 → 157
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cl02570
      Location:191 → 381
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      117723512..117782031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078844.2 → XP_038934772.1  rho GTPase-activating protein 8 isoform X1

      UniProtKB/TrEMBL
      Q6AYD8
      Conserved Domains (2) summary
      cd00170
      Location:12 → 157
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cl02570
      Location:191 → 381
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    Nucleotide Protein Strain
    Heading Accession and Version

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