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    P2RY13 purinergic receptor P2Y13 [ Homo sapiens (human) ]

    Gene ID: 53829, updated on 9-Dec-2024

    Summary

    Official Symbol
    P2RY13provided by HGNC
    Official Full Name
    purinergic receptor P2Y13provided by HGNC
    Primary source
    HGNC:HGNC:4537
    See related
    Ensembl:ENSG00000181631 MIM:606380; AllianceGenome:HGNC:4537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPCR1; GPR86; GPR94; P2Y13; SP174; FKSG77
    Summary
    The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]
    Expression
    Broad expression in spleen (RPKM 21.1), appendix (RPKM 14.3) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See P2RY13 in Genome Data Viewer
    Location:
    3q25.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (151326312..151329549, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (154077312..154080550, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151044100..151047337, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene purinergic receptor P2Y14 Neighboring gene Sharpr-MPRA regulatory region 3159 Neighboring gene SET pseudogene 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:151033994-151035193 Neighboring gene G protein-coupled receptor 87 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20701 Neighboring gene purinergic receptor P2Y12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:151110665-151111260 Neighboring gene Sharpr-MPRA regulatory region 9761 Neighboring gene immunoglobulin superfamily member 10 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    P2Y purinoceptor 13
    Names
    G protein-coupled receptor 86
    G-protein coupled receptor 94
    purinergic receptor P2Y, G-protein coupled, 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176894.3NP_795713.2  P2Y purinoceptor 13

      See identical proteins and their annotated locations for NP_795713.2

      Status: REVIEWED

      Source sequence(s)
      AC024886, DA676457
      Consensus CDS
      CCDS3158.2
      UniProtKB/Swiss-Prot
      B2R827, Q05C50, Q6DKN4, Q8IUT5, Q8TDU7, Q9BPV8, Q9BY61
      UniProtKB/TrEMBL
      G4XH60
      Related
      ENSP00000320376.5, ENST00000325602.6
      Conserved Domains (1) summary
      pfam00001
      Location:62317
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      151326312..151329549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713664.1XP_006713727.1  P2Y purinoceptor 13 isoform X1

      Conserved Domains (1) summary
      PHA03087
      Location:50164
      PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      154077312..154080550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346899.1XP_054202874.1  P2Y purinoceptor 13 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023914.2: Suppressed sequence

      Description
      NM_023914.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to include intronic sequence.