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    TIGD1 tigger transposable element derived 1 [ Homo sapiens (human) ]

    Gene ID: 200765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TIGD1provided by HGNC
    Official Full Name
    tigger transposable element derived 1provided by HGNC
    Primary source
    HGNC:HGNC:14523
    See related
    Ensembl:ENSG00000221944 MIM:612972; AllianceGenome:HGNC:14523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EEYORE
    Summary
    The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
    Orthologs
    all
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    Genomic context

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    See TIGD1 in Genome Data Viewer
    Location:
    2q37.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (232543883..232550557, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (233030667..233037341, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233408593..233415267, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233388351-233388860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233390966-233391619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233398312-233398832 Neighboring gene serine protease 56 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233399875-233400394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17323 Neighboring gene cholinergic receptor nicotinic delta subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12460 Neighboring gene cholinergic receptor nicotinic gamma subunit Neighboring gene microRNA 5001 Neighboring gene eukaryotic translation initiation factor 4E family member 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:233432608-233433807 Neighboring gene uncharacterized LOC105373929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:233465129-233465628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17325 Neighboring gene EF-hand domain family member D1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12461 Neighboring gene Sharpr-MPRA regulatory region 9991 Neighboring gene RNA, 7SL, cytoplasmic 359, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploring Cancer Dependency Map genes and immune subtypes in colon cancer, in which TIGD1 contributes to colon cancer progression. Zhang G, et al. Aging (Albany NY), 2023 Jul 13. PMID 37441804, Free PMC Article
    2. TIGD1, a gene of unknown function, involves cell-cycle progression and correlates with poor prognosis in human cancer. Yin L, et al. J Cell Biochem, 2019 Jun. PMID 30548305
    3. Tiggers and DNA transposon fossils in the human genome. Smit AF, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643651, Free PMC Article
    4. Members of the pogo superfamily of DNA-mediated transposons in the human genome. Robertson HM. Mol Gen Genet, 1996 Oct 28. PMID 8917322
    5. MiR-137 mediated high expression of TIGD1 promotes migration, invasion, and suppresses apoptosis of lung adenocarcinoma. Wei Y, et al. Lung Cancer, 2024 Sep. PMID 39173230

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-137 mediated high expression of TIGD1 promotes migration, invasion, and suppresses apoptosis of lung adenocarcinoma.
      Title: MiR-137 mediated high expression of TIGD1 promotes migration, invasion, and suppresses apoptosis of lung adenocarcinoma.
    2. Exploring Cancer Dependency Map genes and immune subtypes in colon cancer, in which TIGD1 contributes to colon cancer progression.
      Title: Exploring Cancer Dependency Map genes and immune subtypes in colon cancer, in which TIGD1 contributes to colon cancer progression.
    3. inding provides evidence that TIGD1 involve in the cell cycle. These findings provide fresh insight into our understanding of TEs in cancers. Next, the detailed mechanism of TIGD1 needs to be studied in the future.
      Title: TIGD1, a gene of unknown function, involves cell-cycle progression and correlates with poor prognosis in human cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tigger transposable element-derived protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145702.4 → NP_663748.1  tigger transposable element-derived protein 1

      See identical proteins and their annotated locations for NP_663748.1

      Status: VALIDATED

      Source sequence(s)
      AC092165
      Consensus CDS
      CCDS2495.1
      UniProtKB/Swiss-Prot
      Q6P4D2, Q6PIF9, Q96MW7
      Related
      ENSP00000386186.3, ENST00000408957.7
      Conserved Domains (3) summary
      smart00674
      Location:76 → 149
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam03184
      Location:216 → 403
      DDE_1; DDE superfamily endonuclease
      pfam04218
      Location:9 → 60
      CENP-B_N; CENP-B N-terminal DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      232543883..232550557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      233030667..233037341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96MW7.1 GenPept UniProtKB/Swiss-Prot:Q96MW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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