hemL glutamate-1-semialdehyde 2,1-aminomutase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: hemL
Official Full Name: glutamate-1-semialdehyde 2,1-aminomutase
Primary source: ECOCYC:EG10432
Locus tag: b0154
See related: ASAP:ABE-0000529
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0153; gsa; popC
Summary: Mg(2+) stimulon-PhoPQ regulon, EvgAS-PhoPQ cascade enhanced expression subset. [More information is available at EcoGene: EG10432]. Glutamate-1-semialdehyde aminotransferase catalyzes the pyridoxal 5'-phosphate-dependent reaction which converts GSA to delta-aminolevulinate (ALA). [More information is available at EcoCyc: EG10432].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

analysis of glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase complex formation in Escherichia coli during the initial reactions of porphyrin biosynthesis
Title: Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glutamate-1-semialdehyde 2,1-aminomutase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-1-semialdehyde 2,1-aminomutase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tetrapyrrole biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed

NP_414696.1

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