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    ugd UDP-glucose 6-dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946571, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ugd
    Official Full Name
    UDP-glucose 6-dehydrogenase
    Primary source
    ECOCYC:G7091
    Locus tag
    b2028
    See related
    ASAP:ABE-0006734
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2023; pmrE; udg; UDG8; yefA
    Summary
    Salmonella Ugd ortholog is pmrA(basR)-regulated, phoP-regulated, and required for polymyxin resistance and growth in low Mg on solid media. [More information is available at EcoGene: EG13407]. Overproduction of UDP-glucose dehydrogenase reduces production of K5 polysaccharide during exogenous expression of the K5 biosynthesis gene gluster . [More information is available at EcoCyc: G7091].
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    Genomic context

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    Sequence:
    NC_000913.3 (2098447..2099613, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase Neighboring gene O-antigen co-polymerase Neighboring gene 6-phosphogluconate dehydrogenase, decarboxylating Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of UDP-glucose dehydrogenase in Escherichia coli results in decreased biosynthesis of K5 polysaccharide. Roman E, et al. Biochem J, 2003 Sep 15. PMID 12775214, Free PMC Article
    2. Recognition of an unnatural difluorophenyl nucleotide by uracil DNA glycosylase. Jiang YL, et al. Biochemistry, 2004 Dec 14. PMID 15581354
    3. Tyrosine phosphorylation of the UDP-glucose dehydrogenase of Escherichia coli is at the crossroads of colanic acid synthesis and polymyxin resistance. Lacour S, et al. PLoS One, 2008 Aug 25. PMID 18725960, Free PMC Article
    4. Molecular basis of the magnesium deprivation response in Salmonella typhimurium: identification of PhoP-regulated genes. Soncini FC, et al. J Bacteriol, 1996 Sep. PMID 8752324, Free PMC Article
    5. Regulation of polymyxin resistance and adaptation to low-Mg2+ environments. Groisman EA, et al. J Bacteriol, 1997 Nov. PMID 9371451, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables UDP-glucose 6-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 6-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose 6-dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-glucuronate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within colanic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucose 6-dehydrogenase
    NP_416532.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2098447..2099613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416532.1 UDP-glucose 6-dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416532.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7ERF3
      Conserved Domains (1) summary
      PRK15057
      Location:1 → 388
      PRK15057; UDP-glucose 6-dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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