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    recN DNA repair protein RecN [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947105, updated on 17-Dec-2024

    Summary

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    Official Symbol
    recN
    Official Full Name
    DNA repair protein RecN
    Primary source
    ECOCYC:EG10831
    Locus tag
    b2616
    See related
    ASAP:ABE-0008611
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2612; radB
    Summary
    LexA regulon. [More information is available at EcoGene: EG10831]. RecN is required for repair of double strand breaks in the chromosome when these breaks occur at two or more locations, but not when there is a single break in the chromosome. [More information is available at EcoCyc: EG10831].
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    Genomic context

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    Sequence:
    NC_000913.3 (2751795..2753456)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleotide exchange factor GrpE Neighboring gene NAD kinase Neighboring gene outer membrane protein assembly factor BamE Neighboring gene putative component of the Rsx system Neighboring gene ribosome association toxin RatA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protease-deficient SOS constitutive cells have RecN-dependent cell division phenotypes. Warr AR, et al. Mol Microbiol, 2019 Feb. PMID 30422330, Free PMC Article
    2. Lipid deficiency in a lipoprotein mutant of Escherichia coli. Rotering H, et al. FEBS Lett, 1977 Nov 1. PMID 336401
    3. The recN locus of Escherichia coli K12: molecular analysis and identification of the gene product. Picksley SM, et al. Mol Gen Genet, 1985. PMID 3003532
    4. Genetic and phenotypic analyses indicating occurrence of the recN262 and radB101 mutations at the same locus in Escherichia coli. Sargentini NJ, et al. J Bacteriol, 1988 May. PMID 3283110, Free PMC Article
    5. Inducible expression of a gene specific to the RecF pathway for recombination in Escherichia coli K12. Lloyd RG, et al. Mol Gen Genet, 1983. PMID 6343801

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An Epistasis Analysis of recA and recN in Escherichia coli K-12.
      Title: An Epistasis Analysis of recA and recN in Escherichia coli K-12.
    2. UV-irradiated Escherichia coli cells with a recN mutation did not exhibit increased nucleoid condensation, but chromosome replication and cytokinesis occurred. In the uvrA and recJ strains, the condensation step was delayed compared to the wild-type strain, and chromosome replication and cytokinesis did not occur.
      Title: Influence of uvrA, recJ and recN gene mutations on nucleoid reorganization in UV-treated Escherichia coli cells.
    3. The only SOS gene required (of 19 tested) for the cell length phenotype is recN.
      Title: Protease-deficient SOS constitutive cells have RecN-dependent cell division phenotypes.
    4. The DNA damage-induced DNA compaction was found to be dependent on the recombination proteins RecA, RecO and RecR as well as the SOS-inducible, SMC (structural maintenance of chromosomes)-like protein RecN.
      Title: DNA compaction in the early part of the SOS response is dependent on RecN and RecA.
    5. Data suggest that RecN plays a crucial role in homologous recombination-dependent DSB repair and that it is required upstream of RecA-mediated strand exchange.
      Title: RecA protein recruits structural maintenance of chromosomes (SMC)-like RecN protein to DNA double-strand breaks.
    6. a role for RecN in protecting the chromosome from break-induced chromosome rearrangements
      Title: RecN protein and transcription factor DksA combine to promote faithful recombinational repair of DNA double-strand breaks.
    7. ClpXP is a critical factor in the cellular clearance of cytoplasmic RecN aggregates from the cell and therefore plays an important role in DNA damage tolerance
      Title: Degradation of Escherichia coli RecN aggregates by ClpXP protease and its implications for DNA damage tolerance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SOS response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within SOS response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within recombinational interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within recombinational repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in bacterial nucleoid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bacterial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA repair protein RecN

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2751795..2753456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026172.1 DNA repair protein RecN [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026172.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9APR3
      Conserved Domains (1) summary
      PRK10869
      Location:1 → 553
      PRK10869; recombination and repair protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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