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    pssA phosphatidylserine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947059, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pssA
    Official Full Name
    phosphatidylserine synthase
    Primary source
    ECOCYC:EG10781
    Locus tag
    b2585
    See related
    ASAP:ABE-0008510
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2583; pss
    Summary
    The enzyme is a multimer of unknown subunits. [More information is available at EcoCyc: EG10781].
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    Genomic context

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    Sequence:
    NC_000913.3 (2722727..2724082)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA 3-amino-3-carboxypropyltransferase Neighboring gene peptidyl-lysine N-acetyltransferase Neighboring gene protein PssL Neighboring gene DUF2279 domain-containing protein YfiM Neighboring gene alpha-ketoglutarate:H(+) symporter Neighboring gene protein YfiS

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipid dependence and activity control of phosphatidylserine synthase from Escherichia coli. Linde K, et al. FEBS Lett, 2004 Sep 24. PMID 15388336
    2. Interaction of phosphatidylserine synthase from E. coli with lipid bilayers: coupled plasmon-waveguide resonance spectroscopy studies. Salamon Z, et al. Biophys J, 2000 Mar. PMID 10692325, Free PMC Article
    3. Reconstituted phosphatidylserine synthase from Escherichia coli is activated by anionic phospholipids and micelle-forming amphiphiles. Rilfors L, et al. Biochim Biophys Acta, 1999 May 18. PMID 10320811
    4. Phosphatidylserine synthase from bacteria. Matsumoto K. Biochim Biophys Acta, 1997 Sep 4. PMID 9370336
    5. Cloning of genes involved in membrane lipid synthesis. Effects of amplification of phosphatidylserine synthase in Escherichia coli. Ohta A, et al. J Biol Chem, 1981 Mar 10. PMID 6257710

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphatidylserine flux into mitochondria unveiled by organelle-targeted Escherichia coli phosphatidylserine synthase PssA.
      Title: Phosphatidylserine flux into mitochondria unveiled by organelle-targeted Escherichia coli phosphatidylserine synthase PssA.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Sequence and inactivation of the pss gene of Escherichia coli. Phosphatidylethanolamine may not be essential for cell viability.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorus metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylserine synthase
    NP_417080.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2722727..2724082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417080.4 phosphatidylserine synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417080.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H2Z1P2, A0A0H3JHK2, A0A0H3PKM0, A0A376FX41, A0A5B9AQF5, A0A979GGG1, A0AAN3V5H9, C3SYY7, D0VEY9, Q1R8E6, W1EUA3
      Conserved Domains (1) summary
      PRK09428
      Location:1 → 431
      pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase
    Nucleotide Protein
    Heading Accession and Version

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