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    sulA cell division inhibitor SulA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947335, updated on 17-Dec-2024

    Summary

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    Official Symbol
    sulA
    Official Full Name
    cell division inhibitor SulA
    Primary source
    ECOCYC:EG10984
    Locus tag
    b0958
    See related
    ASAP:ABE-0003244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0949; sfiA; suf
    Summary
    Regulation has been described . sulA mRNA stability during glucose starvation is diminished in the absence of |FRAME: [More information is available at EcoCyc: EG10984].
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    Genomic context

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    Sequence:
    NC_000913.3 (1020410..1020919, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene macrodomain Ter protein Neighboring gene outer membrane protein A Neighboring gene transcriptional coactivator for CRP Neighboring gene putative transporter YccS Neighboring gene PF03733 family inner membrane protein YccF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the enterobacterial sulA gene: a component of the SOS system encoding an inhibitor of cell division. Freudl R, et al. Gene, 1987. PMID 3297925
    2. [Role of nitric oxide in the SOS response in Escherichia coli]. Vasil'eva SV, et al. Radiats Biol Radioecol, 2003 Jul-Aug. PMID 14608681
    3. Further characterization of sfiA and sfiB mutations in Escherichia coli. Huisman O, et al. J Bacteriol, 1980 Oct. PMID 6998947, Free PMC Article
    4. Induction by UV light of the SOS function sfiA in Escherichia coli strains deficient or proficient in excision repair. Quillardet P, et al. J Bacteriol, 1984 Jan. PMID 6361003, Free PMC Article
    5. An inducible DNA replication-cell division coupling mechanism in E. coli. Huisman O, et al. Nature, 1981 Apr 30. PMID 7012641

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In current work the recovery of division process of Escherichia coli cells after division arrest due to expression of SOS-response protein SulA was studied. Data indicate that cells are able to rapidly restore normal division; also nucleoid occlusion seems to be the main septum positioning mechanism during the process.
      Title: RECOVERY OF DIVISION PROCESS IN BACTERIAL CELLS AFTER INDUCTION OF SulA PROTEIN WHICH IS RESPONSIBLE FOR CYTOKINESIS ARREST DURING SOS-RESPONSE.
    2. Decrease in FtsZ concentration in the ppGpp(0) strain makes cell division vulnerable to SulA inhibition.
      Title: Inactivation of Cell Division Protein FtsZ by SulA Makes Lon Indispensable for the Viability of a ppGpp0 Strain of Escherichia coli.
    3. Results found that the binding of SulA to FtsZ is necessary but not sufficient for inhibition of FtsZ polymerization.
      Title: Investigation of regulation of FtsZ assembly by SulA and development of a model for FtsZ polymerization.
    4. results indicate existence of a SulA-dependent pathway of high-pressure-induced cell filamentation and suggest involvement of the SOS response, and particularly of SulA, in high-pressure-mediated cell death in strains which are compromised in Lon function
      Title: SulA-dependent hypersensitivity to high pressure and hyperfilamentation after high-pressure treatment of Escherichia coli lon mutants.
    5. kinetics of degradation of SulA by HslV
      Title: Kinetics of protein substrate degradation by HslUV.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SOS response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within SOS response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in division septum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of FtsZ-dependent cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division inhibitor SulA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1020410..1020919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415478.1 cell division inhibitor SulA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415478.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CL81, A0AA36KW46
      Conserved Domains (1) summary
      TIGR00623
      Location:2 → 169
      sula; cell division inhibitor SulA
    Nucleotide Protein
    Heading Accession and Version

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