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    uxuR DNA-binding transcriptional repressor UxuR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948849, updated on 3-Dec-2024

    Summary

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    Official Symbol
    uxuR
    Official Full Name
    DNA-binding transcriptional repressor UxuR
    Primary source
    ECOCYC:EG20249
    Locus tag
    b4324
    See related
    ASAP:ABE-0014179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4315
    Summary
    UxuR regulon. [More information is available at EcoGene: EG20249]. UxuR is a protein that belongs to the GntR family and participates as a regulator in controlling several genes involved in carbon uptake. [More information is available at EcoCyc: EG20249].
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    Genomic context

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    Sequence:
    NC_000913.3 (4554576..4555349)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-mannonate dehydratase Neighboring gene D-mannonate oxidoreductase Neighboring gene DUF2686 domain-containing protein YjiC Neighboring gene protein YtiC Neighboring gene protein YtiD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Use of in vitro gene fusions to study the uxuR regulatory gene in Escherichia coli K-12: direction of transcription and regulation of its expression. Ritzenthaler P, et al. J Bacteriol, 1982 Jun. PMID 6281232, Free PMC Article
    2. Multiple regulation involved in the expression of the uxuR regulatory gene in Escherichia coli K-12. Ritzenthaler P, et al. Mol Gen Genet, 1983. PMID 6406797
    3. Control of hexuronate metabolism in Escherichia coli by the two interdependent regulators, ExuR and UxuR: derepression by heterodimer formation. Tutukina MN, et al. Microbiology (Reading), 2016 Jul. PMID 27129867
    4. Negative dominant mutations of the uidR gene in Escherichia coli: genetic proof for a cooperative regulation of uidA expression. Blanco C, et al. Genetics, 1986 Feb. PMID 3079718, Free PMC Article
    5. GntP is the Escherichia coli Fructuronic acid transporter and belongs to the UxuR regulon. Bates Utz C, et al. J Bacteriol, 2004 Nov. PMID 15516583, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UxuR is essential for rapid growth with D-glucuronate as the primary source of carbon and energy.
      Title: Control of hexuronate metabolism in Escherichia coli by the two interdependent regulators, ExuR and UxuR: derepression by heterodimer formation.
    2. a module of sugar acid catabolism whose physiological role is for growth on fructuronate
      Title: GntP is the Escherichia coli Fructuronic acid transporter and belongs to the UxuR regulon.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor UxuR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4554576..4555349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418744.1 DNA-binding transcriptional repressor UxuR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418744.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8NGI1
      Conserved Domains (1) summary
      PRK10225
      Location:1 → 257
      PRK10225; Uxu operon transcriptional regulator
    Nucleotide Protein
    Heading Accession and Version

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