U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hcr NADH oxidoreductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947660, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hcr
    Official Full Name
    NADH oxidoreductase
    Primary source
    ECOCYC:G6456
    Locus tag
    b0872
    See related
    ASAP:ABE-0002960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0863; ybjV
    Summary
    Hcp is in an operon and associated with its substrate, the Hcp hybrid-cluster protein hydroxylamine reductase. [More information is available at EcoGene: EG13691].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (911182..912150, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene low-specificity L-threonine aldolase Neighboring gene pyruvate oxidase Neighboring gene protein S-nitrosylase Neighboring gene L-lysine/thialysine exporter

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of Escherichia coli class II hybrid cluster protein, HCP, reveals a [4Fe-4S] cluster at the N-terminal protrusion. Fujishiro T, et al. FEBS J, 2021 Dec. PMID 34101368
    2. The roles of the hybrid cluster protein, Hcp and its reductase, Hcr, in high affinity nitric oxide reduction that protects anaerobic cultures of Escherichia coli against nitrosative stress. Wang J, et al. Mol Microbiol, 2016 Jun. PMID 26879449
    3. Genome-wide identification of binding sites for the nitric oxide-sensitive transcriptional regulator NsrR. Efromovich S, et al. Methods Enzymol, 2008. PMID 18433631
    4. Conserved and variable functions of the sigmaE stress response in related genomes. Rhodius VA, et al. PLoS Biol, 2006 Jan. PMID 16336047, Free PMC Article
    5. The hybrid-cluster protein ('prismane protein') from Escherichia coli. Characterization of the hybrid-cluster protein, redox properties of the [2Fe-2S] and [4Fe-2S-2O] clusters and identification of an associated NADH oxidoreductase containing FAD and [2Fe-2S]. van den Berg WA, et al. Eur J Biochem, 2000 Feb. PMID 10651802

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of Escherichia coli class II hybrid cluster protein, HCP, reveals a [4Fe-4S] cluster at the N-terminal protrusion.
      Title: Crystal structure of Escherichia coli class II hybrid cluster protein, HCP, reveals a [4Fe-4S] cluster at the N-terminal protrusion.
    2. In an hcr mutant, Hcp is reversibly inactivated by nitric oxide (NO) concentrations above 200 nM, indicating that Hcr protects Hcp from nitrosylation by its substrate, NO.
      Title: The roles of the hybrid cluster protein, Hcp and its reductase, Hcr, in high affinity nitric oxide reduction that protects anaerobic cultures of Escherichia coli against nitrosative stress.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    NADH oxidoreductase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      911182..912150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415393.1 NADH oxidoreductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415393.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NGK6
      Conserved Domains (1) summary
      PRK10684
      Location:1 → 322
      PRK10684; HCP oxidoreductase, NADH-dependent; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.