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    entC isochorismate synthase EntC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945511, updated on 17-Dec-2024

    Summary

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    Official Symbol
    entC
    Official Full Name
    isochorismate synthase EntC
    Primary source
    ECOCYC:EG10261
    Locus tag
    b0593
    See related
    ASAP:ABE-0002047
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0586; fepF
    Summary
    There are two isochorismate synthase enzymes present in Escherichia coli, encoded by entC and menF. [More information is available at EcoCyc: EG10261].
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    Genomic context

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    Sequence:
    NC_000913.3 (624885..626060)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene enterobactin exporter EntS Neighboring gene ferric enterobactin ABC transporter periplasmic binding protein Neighboring gene 2,3-dihydroxybenzoate-AMP ligase Neighboring gene enterobactin synthase component B Neighboring gene 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase. Jiang M, et al. J Am Chem Soc, 2007 Jan 31. PMID 17243787
    2. Overexpression, purification, and characterization of isochorismate synthase (EntC), the first enzyme involved in the biosynthesis of enterobactin from chorismate. Liu J, et al. Biochemistry, 1990 Feb 13. PMID 2139795
    3. Role of the entC gene in enterobactin and menaquinone biosynthesis in Escherichia coli. Kaiser A, et al. Arch Biochem Biophys, 1990 Feb 1. PMID 2154945
    4. Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes. Sridharan S, et al. J Mol Biol, 2010 Mar 19. PMID 20079748
    5. The in vitro conversion of chorismate to isochorismate catalyzed by the Escherichia coli entC gene product. Evidence that EntA does not contribute to isochorismate synthase activity. Tummuru MK, et al. J Biol Chem, 1989 Dec 5. PMID 2684979

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase.
    2. Intrinsic catalytic efficiency and structure of entC was studied.
      Title: Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables isochorismate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isochorismate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in enterobactin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enterobactin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isochorismate synthase EntC
    NP_415125.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      624885..626060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415125.1 isochorismate synthase EntC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415125.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TPD2, A0A418GP33, A0A478L4Y9, A0A7A6WKR2
      Conserved Domains (1) summary
      PRK15016
      Location:1 → 391
      PRK15016; isochorismate synthase EntC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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