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    mdtC multidrug efflux pump RND permease subunit MdtC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946608, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mdtC
    Official Full Name
    multidrug efflux pump RND permease subunit MdtC
    Primary source
    ECOCYC:G7115
    Locus tag
    b2076
    See related
    ASAP:ABE-0006877
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2072; yegO
    Summary
    mdtABC overexpression confers resistance to deoxycholate and novobiocin. [More information is available at EcoGene: EG14058]. In response regulator overproduction studies and deletion mutation experiments , the mdtABCD (yegMNOB) genes were found to constitute a multidrug resistance cluster which is regulated by the response regulator BaeR. [More information is available at EcoCyc: G7115].
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    Genomic context

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    Sequence:
    NC_000913.3 (2158386..2161463)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion protein MdtA Neighboring gene multidrug efflux pump RND permease subunit MdtB Neighboring gene putative multidrug efflux pump MdtD Neighboring gene sensor histidine kinase BaeS Neighboring gene DNA-binding transcriptional activator BaeR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimer. Kim HS, et al. J Bacteriol, 2010 Mar. PMID 20038594, Free PMC Article
    2. AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export in Escherichia coli. Horiyama T, et al. PLoS One, 2014. PMID 25259870, Free PMC Article
    3. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. Baranova N, et al. J Bacteriol, 2002 Aug. PMID 12107134, Free PMC Article
    4. Global landscape of cell envelope protein complexes in Escherichia coli. Babu M, et al. Nat Biotechnol, 2018 Jan. PMID 29176613, Free PMC Article
    5. Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Hirakawa H, et al. J Antimicrob Chemother, 2003 Oct. PMID 12951338

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of efflux pump complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of efflux pump complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multidrug efflux pump RND permease subunit MdtC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2158386..2161463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416580.1 multidrug efflux pump RND permease subunit MdtC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416580.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JW53
      Conserved Domains (1) summary
      PRK10614
      Location:1 → 1025
      PRK10614; multidrug efflux system subunit MdtC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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