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    zwf NADP(+)-dependent glucose-6-phosphate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946370, updated on 3-Dec-2024

    Summary

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    Official Symbol
    zwf
    Official Full Name
    NADP(+)-dependent glucose-6-phosphate dehydrogenase
    Primary source
    ECOCYC:EG11221
    Locus tag
    b1852
    See related
    ASAP:ABE-0006171
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1853
    Summary
    Residues 199-203 of zwf encode a NNWDN peptide involved in ChpA(MazF) toxicity that is likely converted to NNWNN by AsnA; a zwf deletion prevents NNWNN activity (Kolodkin-Gal, 2007). [More information is available at EcoGene: EG11221]. A null mutation in the zwf gene encoding glucose 6-phosphate-1-dehydrogenase does not affect the growth rate significantly. [More information is available at EcoCyc: EG11221].
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    Genomic context

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    Sequence:
    NC_000913.3 (1934839..1936314, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene KHG/KDPG aldolase Neighboring gene phosphogluconate dehydratase Neighboring gene DNA-binding transcriptional repressor YebK Neighboring gene pyruvate kinase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of mutations affecting expression level and growth rate-dependent regulation of the Escherichia coli zwf gene. Rowley DL, et al. J Bacteriol, 1992 Jan. PMID 1729252, Free PMC Article
    2. Growth-rate recovery of Escherichia coli cultures carrying a multicopy plasmid, by engineering of the pentose-phosphate pathway. Flores S, et al. Biotechnol Bioeng, 2004 Aug 20. PMID 15286986
    3. Glucose-6-phosphate dehydrogenase from Escherichia coli and from a "high-level" mutant. Banerjee S, et al. J Bacteriol, 1972 Apr. PMID 4401601, Free PMC Article
    4. Effect of zwf gene knockout on the metabolism of Escherichia coli grown on glucose or acetate. Zhao J, et al. Metab Eng, 2004 Apr. PMID 15113569
    5. Regulatory mechanisms involving nicotinamide adenine nucleotides as allosteric effectors. 3. Control of glucose 6-phosphate dehydrogenase. Sanwal BD. J Biol Chem, 1970 Apr 10. PMID 4392411

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G6PDH and FPR could act concertedly to deliver reducing equivalents from carbohydrates, via NADP(+), to the FPR acceptors ferredoxin and/or flavodoxin.
      Title: Glucose-6-phosphate dehydrogenase and ferredoxin-NADP(H) reductase contribute to damage repair during the soxRS response of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glucose-6-phosphate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose-6-phosphate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in quorum sensing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within quorum sensing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADP(+)-dependent glucose-6-phosphate dehydrogenase
    NP_416366.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1934839..1936314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416366.1 NADP(+)-dependent glucose-6-phosphate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2W6Q642
      Conserved Domains (1) summary
      PRK05722
      Location:1 → 489
      PRK05722; glucose-6-phosphate 1-dehydrogenase; Validated
    Nucleotide Protein
    Heading Accession and Version

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