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    galF UTP:glucose-1-phosphate uridylyltransferase, low activity [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946560, updated on 3-Dec-2024

    Summary

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    Official Symbol
    galF
    Official Full Name
    UTP:glucose-1-phosphate uridylyltransferase, low activity
    Primary source
    ECOCYC:G7093
    Locus tag
    b2042
    See related
    ASAP:ABE-0006771
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2036; wcaN; yefG
    Summary
    Not required for colanic acid synthesis. [More information is available at EcoGene: EG13578]. GalF stabilizes and may be complexed with the |FRAME: [More information is available at EcoCyc: G7093].
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    Genomic context

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    Sequence:
    NC_000913.3 (2113434..2114327, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene glucose-1-phosphate thymidylyltransferase 1 Neighboring gene dTDP-4-dehydrorhamnose reductase Neighboring gene dTDP-glucose 4,6-dehydratase 1 Neighboring gene putative colanic acid biosynthesis protein WcaM Neighboring gene putative colanic acid biosynthesis glycosyl transferase WcaL Neighboring gene colanic acid biosynthesis pyruvyl transferase WcaK

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. On the Ancestral UDP-Glucose Pyrophosphorylase Activity of GalF from Escherichia coli. Ebrecht AC, et al. Front Microbiol, 2015. PMID 26617591, Free PMC Article
    2. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
    3. CONTROL ASPECTS OF URIDINE 5'-DIPHOSPHATE GLUCOSE AND THYMIDINE 5'-DIPHOSPHATE GLUCOSE SYNTHESIS BY MICROBIAL ENZYMES. BERNSTEIN RL, et al. J Biol Chem, 1965 Jan. PMID 14253441
    4. UTP: alpha-D-glucose-1-phosphate uridylyltransferase of Escherichia coli: isolation and DNA sequence of the galU gene and purification of the enzyme. Weissborn AC, et al. J Bacteriol, 1994 May. PMID 8169209, Free PMC Article
    5. The GalF protein of Escherichia coli is not a UDP-glucose pyrophosphorylase but interacts with the GalU protein possibly to regulate cellular levels of UDP-glucose. Marolda CL, et al. Mol Microbiol, 1996 Dec. PMID 8971705

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables UTP:glucose-1-phosphate uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-alpha-D-glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-sugar metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UTP:glucose-1-phosphate uridylyltransferase, low activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2113434..2114327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416546.1 UTP:glucose-1-phosphate uridylyltransferase, low activity [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416546.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0A8J5A0
      Conserved Domains (1) summary
      PRK10122
      Location:1 → 297
      PRK10122; UTP--glucose-1-phosphate uridylyltransferase GalF
    Nucleotide Protein
    Heading Accession and Version

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