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    thiK thiamine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948525, updated on 3-Dec-2024

    Summary

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    Official Symbol
    thiK
    Official Full Name
    thiamine kinase
    Primary source
    ECOCYC:G6566
    Locus tag
    b1106
    See related
    ASAP:ABE-0003735
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1092; ycfN
    Summary
    The thiK locus was mapped , and the ycfN open reading frame has recently been identified as the structural gene encoding thiamine kinase . [More information is available at EcoCyc: G6566].
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    Genomic context

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    Sequence:
    NC_000913.3 (1163260..1164084)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene purine nucleoside phosphoramidase Neighboring gene DUF1425 domain-containing protein YcfL Neighboring gene outer membrane lipoprotein - activator of MrcB activity Neighboring gene beta-N-acetylglucosaminidase Neighboring gene PF05728 family protein YcfP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conversion of thiamine to thiamine monophosphate by cell-free extracts of Escherichia coli. Iwashima A, et al. Biochim Biophys Acta, 1972 Jan 20. PMID 4550803
    2. thiK and thiL loci of Escherichia coli. Imamura N, et al. J Bacteriol, 1982 Aug. PMID 6284709, Free PMC Article
    3. Thiamin biosynthesis in prokaryotes. Begley TP, et al. Arch Microbiol, 1999 Apr. PMID 10382260
    4. Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase. Melnick J, et al. J Bacteriol, 2004 Jun. PMID 15150256, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thiamine kinase
    NP_415624.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1163260..1164084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415624.1 thiamine kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415624.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5ZVD7
      Conserved Domains (1) summary
      PRK10271
      Location:87 → 274
      thiK; thiamine kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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