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    Atp8b3 ATPase, class I, type 8B, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 67331, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Atp8b3provided by MGI
    Official Full Name
    ATPase, class I, type 8B, member 3provided by MGI
    Primary source
    MGI:MGI:1914581
    See related
    Ensembl:ENSMUSG00000003341 AllianceGenome:MGI:1914581
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ATPIK; SAPLT; 1700042F02Rik; 1700056N23Rik
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Acts upstream of or within binding activity of sperm to zona pellucida; establishment of localization in cell; and phospholipid translocation. Located in acrosomal vesicle and membrane. Is expressed in several structures, including heart; testis; trunk; and white fat. Orthologous to human ATP8B3 (ATPase phospholipid transporting 8B3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward testis adult (RPKM 456.8) See more
    Orthologs
    human all
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    Genomic context

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    See Atp8b3 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80355418..80374987, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80519584..80539154, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40716 Neighboring gene one cut domain, family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1124 Neighboring gene REX1, RNA exonuclease 1 Neighboring gene predicted gene, 31057 Neighboring gene STARR-positive B cell enhancer ABC_E10628 Neighboring gene STARR-positive B cell enhancer mm9_chr10:80032416-80032717 Neighboring gene Kruppel-like transcription factor 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase. Gong EY, et al. Reproduction, 2009 Feb. PMID 19017724
    2. A novel aminophospholipid transporter exclusively expressed in spermatozoa is required for membrane lipid asymmetry and normal fertilization. Wang L, et al. Dev Biol, 2004 Mar 1. PMID 14975727
    3. Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. Hong S, et al. J Biol Chem, 2005 Mar 4. PMID 15613475
    4. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. Chiellini C, et al. J Cell Physiol, 2003 May. PMID 12652657
    5. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine floppase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase IK
    Names
    sperm aminophospholipid transporter
    spermatozoan aminophospholipid translocase
    NP_080370.2
    XP_006514047.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026094.3 → NP_080370.2  phospholipid-transporting ATPase IK

      Status: PROVISIONAL

      Source sequence(s)
      AY364445
      Consensus CDS
      CCDS24024.1
      UniProtKB/Swiss-Prot
      Q6UQ17
      Related
      ENSMUSP00000020383.5, ENSMUST00000020383.6
      Conserved Domains (5) summary
      COG4087
      Location:839 → 890
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01652
      Location:45 → 1131
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam13246
      Location:483 → 580
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:20 → 96
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:883 → 1131
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80355418..80374987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513984.3 → XP_006514047.1  phospholipid-transporting ATPase IK isoform X1

      Conserved Domains (1) summary
      cd02073
      Location:47 → 969
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RNA

    1. XR_380430.5 RNA Sequence

      Related
      ENSMUST00000220326.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UQ17.1 GenPept UniProtKB/Swiss-Prot:Q6UQ17

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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