Fndc4 fibronectin type III domain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fndc4provided by MGI
Official Full Name: fibronectin type III domain containing 4provided by MGI
Primary source: MGI:MGI:1917195
See related: Ensembl:ENSMUSG00000038552 AllianceGenome:MGI:1917195
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FRCP1; Fnmp1; 2810430J06Rik; 6330410H20Rik
Summary: Involved in negative regulation of inflammatory response. Located in endoplasmic reticulum; extracellular space; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FNDC4 (fibronectin type III domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in limb E14.5 (RPKM 37.1), CNS E18 (RPKM 36.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.27 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31449589..31453279, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31292242..31295935, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Title: Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Fibronectin type III domain containing four promotes differentiation of C2C12 through the Wnt/beta-catenin signaling pathway.
Title: Fibronectin type III domain containing four promotes differentiation of C2C12 through the Wnt/β-catenin signaling pathway.
FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10
Title: FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB Activation and CXCL10 Expression.
The HO-1-mediated pathway is involved in the suppressive effects of FNDC4 on inflammation and insulin resistance.
Title: Fibronectin Type III Domain Containing 4 attenuates hyperlipidemia-induced insulin resistance via suppression of inflammation and ER stress through HO-1 expression in adipocytes.
FNDC4 as a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.
Title: FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

AI838506 (e-PCR)
- UniSTS:165389

Fndc4 (e-PCR), detects polymorphism
- UniSTS:547981

NoName (e-PCR)
- UniSTS:235159

AW487863 (e-PCR)
- UniSTS:179148

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in response to transforming growth factor beta	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fibronectin type III domain-containing protein 4

Names: fibronectin type III repeat containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356945.2 → NP_001343874.1 fibronectin type III domain-containing protein 4 isoform a precursor

Status: VALIDATED

Source sequence(s)

AC114619

Conserved Domains (1) summary

cd00063
Location:43 → 133

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001356946.2 → NP_001343875.1 fibronectin type III domain-containing protein 4 isoform b precursor

Status: VALIDATED

Source sequence(s)

AC114619

Consensus CDS

CCDS19181.1

UniProtKB/Swiss-Prot

Q3TR08, Q810E5, Q9CYY4

UniProtKB/TrEMBL

A0A0J9YUI2, B9EI95

Related

ENSMUSP00000047185.8, ENSMUST00000041266.11

Conserved Domains (1) summary

cd00063
Location:43 → 133

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001378890.1 → NP_001365819.1 fibronectin type III domain-containing protein 4 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC114619

Conserved Domains (1) summary

cd00063
Location:43 → 133

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_022424.7 → NP_071869.2 fibronectin type III domain-containing protein 4 isoform b precursor

See identical proteins and their annotated locations for NP_071869.2

Status: VALIDATED

Source sequence(s)

AC114619

Consensus CDS

CCDS19181.1

UniProtKB/Swiss-Prot

Q3TR08, Q810E5, Q9CYY4

UniProtKB/TrEMBL

A0A0J9YUI2, B9EI95

Related

ENSMUSP00000127404.2, ENSMUST00000172435.8

Conserved Domains (1) summary

cd00063
Location:43 → 133

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...