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    fads2 fatty acid desaturase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 140615, updated on 4-Jan-2025

    Summary

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    Official Symbol
    fads2provided by ZNC
    Official Full Name
    fatty acid desaturase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-011212-1
    See related
    Ensembl:ENSDARG00000019532 AllianceGenome:ZFIN:ZDB-GENE-011212-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Fadsd6; DRD5/D6; wu:fb64c04; wu:fb69e08; zgc:112502
    Summary
    Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Acts upstream of or within liver development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alar plate midbrain region; fat cell; nervous system; optic vesicle; and pleuroperitoneal region. Orthologous to several human genes including FADS2 (fatty acid desaturase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See fads2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (4133489..4148719, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (4007830..4023060, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene EPS8 signaling adaptor L2 Neighboring gene uncharacterized LOC137489317 Neighboring gene uncharacterized LOC137489318 Neighboring gene leucine rich repeat containing 10B Neighboring gene stabilizer of axonemal microtubules 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Delta-8 desaturation activity varies among fatty acyl desaturases of teleost fish: high activity in delta-6 desaturases of marine species. Monroig O, et al. Comp Biochem Physiol B Biochem Mol Biol, 2011 Aug. PMID 21571087
    2. Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. Ashikawa Y, et al. Heliyon, 2017 Mar. PMID 28367511, Free PMC Article
    3. Identification of amino acid residues that determine the substrate specificity of mammalian membrane-bound front-end fatty acid desaturases. Watanabe K, et al. J Lipid Res, 2016 Jan. PMID 26590171, Free PMC Article
    4. Partial fads2 Gene Knockout Diverts LC-PUFA Biosynthesis via an Alternative Δ8 Pathway with an Impact on the Reproduction of Female Zebrafish (Danio rerio). Bláhová Z, et al. Genes (Basel), 2022 Apr 15. PMID 35456508, Free PMC Article
    5. Transcriptional activation of zebrafish fads2 promoter and its transient transgene expression in yolk syncytial layer of zebrafish embryos. Tay SS, et al. Sci Rep, 2018 Mar 1. PMID 29497119, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis.
      Title: Integrated transcriptome and phosphoproteome analyses reveal that fads2 is critical for maintaining body LC-PUFA homeostasis.
    2. these results implicate that Z-FADS, the sole fatty acid desaturase ever been identified in zebrafish, can serve as a universal fatty acid desaturase during lipogenesis.
      Title: Identification of the proteins required for fatty acid desaturation in zebrafish (Danio rerio).
    3. desaturase displayed significant upregulation in expression during the oocyte maturation stage.
      Title: Upregulated mRNA expression of desaturase and elongase, two enzymes involved in highly unsaturated fatty acids biosynthesis pathways during follicle maturation in zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyl-CoA delta5-desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables linoleoyl-CoA desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA 6-desaturase
    Names
    D5D/D6D fatty acid desaturase
    delta(5)/Delta(6) fatty acid desaturase
    delta-6 fatty acyl desaturase
    NP_571720.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131645.2 → NP_571720.2  acyl-CoA 6-desaturase

      See identical proteins and their annotated locations for NP_571720.2

      Status: PROVISIONAL

      Source sequence(s)
      BC049438
      UniProtKB/Swiss-Prot
      Q7ZWF3, Q9DEX7
      Related
      ENSDARP00000022396.6, ENSDART00000023278.7
      Conserved Domains (3) summary
      PLN03199
      Location:21 → 439
      PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional
      cd03506
      Location:162 → 412
      Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
      pfam00173
      Location:21 → 94
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      4133489..4148719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DEX7.1 GenPept UniProtKB/Swiss-Prot:Q9DEX7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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