ska2 spindle and kinetochore associated complex subunit 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ska2provided by ZNC
Official Full Name: spindle and kinetochore associated complex subunit 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-041008-202
See related: Ensembl:ENSDARG00000114038 AllianceGenome:ZFIN:ZDB-GENE-041008-202
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7140390
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore and regulation of microtubule polymerization or depolymerization. Predicted to act upstream of or within cell division. Predicted to be located in meiotic spindle. Predicted to be part of outer kinetochore. Predicted to be active in spindle microtubule. Orthologous to human SKA2 (spindle and kinetochore associated complex subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (33369599..33379644, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (33425739..33435784, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule polymerization or depolymerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in meiotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of outer kinetochore	IBA Inferred from Biological aspect of Ancestor more info
part_of outer kinetochore	IEA Inferred from Electronic Annotation more info
part_of outer kinetochore	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SKA complex subunit 2

Names: spindle and KT associated 2; spindle and kinetochore-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199675.1 → NP_001186604.1 SKA complex subunit 2

Status: VALIDATED

Source sequence(s)

BC129466, BX088525, EH465311

UniProtKB/Swiss-Prot

Q0P426

UniProtKB/TrEMBL

A0A2R8QLG0, A0A8M1NVI6

Related

ENSDARP00000153338.1, ENSDART00000186924.1

Conserved Domains (1) summary

cd12955
Location:4 → 120

SKA2; Spindle and kinetochore-associated protein 2