tnnt2a troponin T type 2a (cardiac) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnnt2aprovided by ZNC
Official Full Name: troponin T type 2a (cardiac)provided by ZNC
Primary source: ZFIN:ZDB-GENE-000626-1
See related: Ensembl:ENSDARG00000020610 AllianceGenome:ZFIN:ZDB-GENE-000626-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cTnT; ctnnt; tnnt2
Summary: Predicted to enable cytoskeletal protein binding activity and protein-macromolecule adaptor activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within several processes, including circulatory system development; hematopoietic stem cell differentiation; and nitric oxide biosynthetic process. Part of troponin complex. Is expressed in cardiac muscle; cardiovascular system; and mesoderm. Used to study cardiomyopathy and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (5653173..5685045, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (5719198..5751126, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data showed that CXCR4a was significantly more highly expressed in tnnt2 knocked down mutant at 48 and 60 hpf than controls.
Title: Microarray profiling reveals CXCR4a is downregulated by blood flow in vivo and mediates collateral formation in zebrafish embryos.
Tnnt1, Tnnt2, and Tnnt3b were conserved in the central tropomyosin- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 and Tnnt2, but not Tnnt3b.
Title: Molecular structure and developmental expression of three muscle-type troponin T genes in zebrafish.
We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.
Title: Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.

Submit: New GeneRIF Correction

General gene information

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Markers

tnnt2 (e-PCR), detects polymorphism
- UniSTS:205481

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables cytoskeletal protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tropomyosin binding	ISS Inferred from Sequence or Structural Similarity more info
enables troponin C binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin I binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within artery development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within atrial cardiac muscle tissue morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within blood circulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphoid lineage cell migration into thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within striated muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within venous blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular cardiac muscle tissue morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in myofibril	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcomere	ISS Inferred from Sequence or Structural Similarity more info
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IEA Inferred from Electronic Annotation more info
part_of troponin complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: troponin T type 2a (cardiac)

Names: sih; silent heart; troponin T2, cardiac; troponin T2a, cardiac

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.