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    ssh1b slingshot protein phosphatase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 567479, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ssh1bprovided by ZNC
    Official Full Name
    slingshot protein phosphatase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5909
    See related
    Ensembl:ENSDARG00000010031 AllianceGenome:ZFIN:ZDB-GENE-030131-5909
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi24e04; wu:fi24e04; si:dkey-202g15.7
    Summary
    Predicted to enable actin binding activity and myosin phosphatase activity. Predicted to act upstream of or within negative regulation of actin filament polymerization and protein dephosphorylation. Orthologous to human SSH1 (slingshot protein phosphatase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ssh1b in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (31914914..31929058, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31315269..31329480, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 119b Neighboring gene coronin, actin binding protein, 1Cb Neighboring gene uracil DNA glycosylase b Neighboring gene uncharacterized LOC137495602 Neighboring gene SV2 related protein b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase Slingshot homolog 1
    Names
    slingshot homolog 1b
    XP_021332184.1
    XP_695867.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      31914914..31929058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476509.2 → XP_021332184.1  protein phosphatase Slingshot homolog 1

      UniProtKB/TrEMBL
      A0A8N7UVI6
      Related
      ENSDARP00000148898.1, ENSDART00000187340.1
      Conserved Domains (3) summary
      cd11652
      Location:3 → 236
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:307 → 443
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:244 → 302
      DEK_C; DEK C terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394585.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      232319..246463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_690775.8 → XP_695867.2  protein phosphatase Slingshot homolog 1

      UniProtKB/TrEMBL
      A0A8N7UVI6
      Conserved Domains (3) summary
      cd11652
      Location:3 → 236
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:307 → 443
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:244 → 302
      DEK_C; DEK C terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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