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    wdr37 WD repeat domain 37 [ Danio rerio (zebrafish) ]

    Gene ID: 558075, updated on 27-Dec-2024

    Summary

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    Official Symbol
    wdr37provided by ZNC
    Official Full Name
    WD repeat domain 37provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8101
    See related
    Ensembl:ENSDARG00000074611 AllianceGenome:ZFIN:ZDB-GENE-030131-8101
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj52e09; im:7144367; wu:fj52e09
    Summary
    Is expressed in several structures, including digestive system; immature eye; nervous system; pharyngeal arch; and skeletal muscle. Human ortholog(s) of this gene implicated in neurooculocardiogenitourinary syndrome. Orthologous to human WDR37 (WD repeat domain 37). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wdr37 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (3478954..3527978)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (3447141..3496191)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene NCK adaptor protein 1b Neighboring gene solute carrier family 35 member G2b Neighboring gene isopentenyl-diphosphate delta isomerase 1 Neighboring gene adenosine deaminase RNA specific B2 (inactive) Neighboring gene uncharacterized LOC137489203 Neighboring gene uncharacterized LOC137489280

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. De Novo Missense Variants in WDR37 Cause a Severe Multisystemic Syndrome. Reis LM, et al. Am J Hum Genet, 2019 Aug 1. PMID 31327510, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168264.1 → NP_001161736.1  WD repeat-containing protein 37

      Status: PROVISIONAL

      Source sequence(s)
      AL954666, CT583671
      UniProtKB/TrEMBL
      A0A8M1NVS2, E7FEE4
      Related
      ENSDARP00000114888.1, ENSDART00000134598.3
      Conserved Domains (3) summary
      COG2319
      Location:124 → 486
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:148 → 484
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:159 → 197
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      3478954..3527978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297244.4 → XP_009295519.1  WD repeat-containing protein 37 isoform X1

      See identical proteins and their annotated locations for XP_009295519.1

      UniProtKB/TrEMBL
      A0A8M3AVV6
      Conserved Domains (3) summary
      COG2319
      Location:175 → 514
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:176 → 512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:187 → 225
      7WD40; WD40 repeat [structural motif]

    2. XM_068217084.1 → XP_068073185.1  WD repeat-containing protein 37 isoform X2

      UniProtKB/TrEMBL
      A0A8M1NVS2, E7FEE4
      Related
      ENSDARP00000099166.2, ENSDART00000111491.4

    3. XM_009297245.4 → XP_009295520.1  WD repeat-containing protein 37 isoform X1

      See identical proteins and their annotated locations for XP_009295520.1

      UniProtKB/TrEMBL
      A0A8M3AVV6
      Conserved Domains (3) summary
      COG2319
      Location:175 → 514
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:176 → 512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:187 → 225
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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