vcam1b vascular cell adhesion molecule 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vcam1bprovided by ZNC
Official Full Name: vascular cell adhesion molecule 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070209-238
See related: Ensembl:ENSDARG00000062479 AllianceGenome:ZFIN:ZDB-GENE-070209-238
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: vcam1; fi76d06; wu:fi76d06; zgc:158875
Summary: Predicted to enable integrin binding activity. Acts upstream of or within lymphangiogenesis. Predicted to be located in membrane. Is expressed in several structures, including basal plate midbrain region; cardiovascular system; central nervous system; periderm; and trunk. Human ortholog(s) of this gene implicated in gastrointestinal system disease and hypertension. Orthologous to human VCAM1 (vascular cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (16170995..16179954, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (16144493..16154596, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study provides insights into the mechanism of haematopoietic stem and progenitor cells (HSPC) homing and reveals the essential role of a VCAM-1(+) macrophage population with patrolling behaviour in HSPC retention
Title: VCAM-1(+) macrophages guide the homing of HSPCs to a vascular niche.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymphangiogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vascular cell adhesion protein 1b

Names: vascular cell adhesion molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083835.1 → NP_001077304.1 vascular cell adhesion protein 1b precursor

Status: PROVISIONAL

Source sequence(s)

CU458903

UniProtKB/TrEMBL

A0A8M6Z3D7, A4JYI2, A5PMX0

Related

ENSDARP00000144690.1, ENSDART00000185607.1

Conserved Domains (4) summary

cd00096
Location:405 → 471

Ig; Immunoglobulin domain

smart00410
Location:216 → 293

IG_like; Immunoglobulin like

pfam13895
Location:588 → 671

Ig_2; Immunoglobulin domain

cl11960
Location:210 → 286

Ig; Immunoglobulin domain