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    myo1cb myosin Ic, paralog b [ Danio rerio (zebrafish) ]

    Gene ID: 566459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    myo1cbprovided by ZNC
    Official Full Name
    myosin Ic, paralog bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090429-3
    See related
    Ensembl:ENSDARG00000061579 AllianceGenome:ZFIN:ZDB-GENE-090429-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    myo1c; fj81f11; wu:fj81f11
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within glomerulus development. Predicted to be located in stereocilium membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Is expressed in several structures, including digestive system; head; notochord; pectoral fin; and pronephric glomerulus. Orthologous to human MYO1C (myosin IC). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See myo1cb in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (28268141..28352516)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (28335265..28418293)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein Neighboring gene pre-mRNA processing factor 8 Neighboring gene si:dkey-118k5.3 Neighboring gene solute carrier family 43 member 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos. Gupta P, et al. PLoS One, 2017. PMID 28678859, Free PMC Article
    2. Vascular toxicity of ultra-small TiO2 nanoparticles and single walled carbon nanotubes in vitro and in vivo. Bayat N, et al. Biomaterials, 2015 Sep. PMID 26066004
    3. Myo1c is an unconventional myosin required for zebrafish glomerular development. Arif E, et al. Kidney Int, 2013 Dec. PMID 23715127, Free PMC Article
    4. Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish. Kamstra JH, et al. Sci Rep, 2018 Oct 18. PMID 30337673, Free PMC Article
    5. Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry. Juan T, et al. Nat Commun, 2018 May 16. PMID 29769531, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate a potential role for Myo1 in the maintenance and formation of furrow, blastodisc morphology, cell-division and lipid droplets (LDs) organization within the blastodisc during early embryogenesis.
      Title: Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos.
    2. Myo1c is necessary for podocyte morphogenesis.
      Title: Myo1c is an unconventional myosin required for zebrafish glomerular development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stereocilium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin Ic, paralog b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317189.1 → NP_001304118.1  myosin Ic, paralog b

      Status: VALIDATED

      Source sequence(s)
      CR478288, CR522882
      UniProtKB/TrEMBL
      A0A286Y9H2, A0A2R8Q9G7, A0A8M1P762
      Related
      ENSDARP00000149786.1, ENSDART00000188550.1
      Conserved Domains (3) summary
      smart00242
      Location:49 → 736
      MYSc; Myosin. Large ATPases
      cd01378
      Location:68 → 723
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:879 → 1046
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      28268141..28352516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157668.5 → XP_005157725.1  myosin Ic, paralog b isoform X2

      UniProtKB/TrEMBL
      A0A286Y9H2, A0A8M3APY8, R4GDM7
      Related
      ENSDARP00000126580.1, ENSDART00000152777.3
      Conserved Domains (2) summary
      cd01378
      Location:28 → 683
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:839 → 1020
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    2. XM_005157667.5 → XP_005157724.1  myosin Ic, paralog b isoform X1

      UniProtKB/TrEMBL
      A0A286Y9H2, A0A8M2B4J2, E7F5R7
      Related
      ENSDARP00000082359.6, ENSDART00000087926.6
      Conserved Domains (3) summary
      smart00242
      Location:24 → 711
      MYSc; Myosin. Large ATPases
      cd01378
      Location:43 → 698
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:854 → 1021
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    Nucleotide Protein
    Heading Accession and Version

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