ndnf neuron-derived neurotrophic factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ndnfprovided by ZNC
Official Full Name: neuron-derived neurotrophic factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-207
See related: Ensembl:ENSDARG00000062936 AllianceGenome:ZFIN:ZDB-GENE-030131-207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb16h09
Summary: Involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus. Acts upstream of or within embryonic neurocranium morphogenesis. Predicted to be located in extracellular region. Is expressed in central nervous system; cranial ganglion; hypochord; somite; and stomodeum. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NDNF (neuron derived neurotrophic factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (2052998..2099410, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (2042646..2084632, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb16h09.x1 (e-PCR)
- UniSTS:190199

fb16h09.x1 (e-PCR)
- UniSTS:190200

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to fibroblast growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within embryonic neurocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein NDNF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.