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    sfxn5b sideroflexin 5b [ Danio rerio (zebrafish) ]

    Gene ID: 561995, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sfxn5bprovided by ZNC
    Official Full Name
    sideroflexin 5bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050706-107
    See related
    Ensembl:ENSDARG00000026137 AllianceGenome:ZFIN:ZDB-GENE-050706-107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc52e09; zgc:114137
    Summary
    Predicted to enable citrate transmembrane transporter activity. Predicted to be involved in citrate transport and mitochondrial transmembrane transport. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SFXN5 (sideroflexin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sfxn5b in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (45306031..45335712)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (46318776..46348420)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene BEN domain containing 4 Neighboring gene RAB11 family interacting protein 5b (class I) Neighboring gene zgc:153018 Neighboring gene tetratricopeptide repeat domain 9C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Sfxn5 Regulation of Actin Polymerization for Neutrophil Spreading Depends on a Citrate-Cholesterol-PI(4,5)P2 Pathway. Zhang H, et al. J Immunol, 2023 Aug 1. PMID 37326485
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114137

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sideroflexin-5b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030163.3 → NP_001025334.2  sideroflexin-5b

      Status: VALIDATED

      Source sequence(s)
      CR847510
      UniProtKB/TrEMBL
      A0A8M2BH13, F1R7K0, Q4KM09
      Related
      ENSDARP00000142582.1, ENSDART00000173301.2
      Conserved Domains (1) summary
      pfam03820
      Location:17 → 325
      Mtc; Tricarboxylate carrier

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      45306031..45335712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481035.2 → XP_021336710.1  sideroflexin-5b isoform X1

      UniProtKB/TrEMBL
      A0A8M9QP64
      Conserved Domains (1) summary
      pfam03820
      Location:44 → 264
      Mtc; Tricarboxylate carrier

    RNA

    1. XR_002459914.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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