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    lmnb2 lamin B2 [ Danio rerio (zebrafish) ]

    Gene ID: 30196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lmnb2provided by ZNC
    Official Full Name
    lamin B2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990630-13
    See related
    Ensembl:ENSDARG00000101624 AllianceGenome:ZFIN:ZDB-GENE-990630-13
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lamin; fc15d06; im:7142331; wu:fb94e05; wu:fb95e12; wu:fc15d06; wu:fc49h03
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Located in nuclear envelope. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lmnb2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (3121086..3152357, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (3103813..3135084, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene impact RWD domain protein Neighboring gene histamine H3 receptor Neighboring gene ribosomal protein L36 Neighboring gene lon peptidase 1, mitochondrial

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The lamin CxxM motif promotes nuclear membrane growth. Prüfert K, et al. J Cell Sci, 2004 Dec 1. PMID 15546914
    2. Combined haploid and insertional mutation screen in the zebrafish. Wiellette E, et al. Genesis, 2004 Dec. PMID 15593329
    3. ngs (notochord granular surface) gene encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish. Tong X, et al. J Biol Chem, 2013 Jan 25. PMID 23132861, Free PMC Article
    4. Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development. Strasser MJ, et al. BMC Dev Biol, 2008 May 28. PMID 18507824, Free PMC Article
    5. Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Ho M, et al. Hum Genomics, 2022 Jan 6. PMID 34991727, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lamin-B2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131002.2 → NP_571077.2  lamin-B2

      See identical proteins and their annotated locations for NP_571077.2

      Status: VALIDATED

      Source sequence(s)
      CU550710
      UniProtKB/TrEMBL
      A0A8M1P6M8, B3DFN3
      Related
      ENSDARP00000139279.1, ENSDART00000170983.2
      Conserved Domains (3) summary
      pfam00038
      Location:25 → 381
      Filament; Intermediate filament protein
      pfam00932
      Location:433 → 542
      LTD; Lamin Tail Domain
      cl19219
      Location:300 → 371
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      3121086..3152357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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