dennd10 DENN domain containing 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dennd10provided by ZNC
Official Full Name: DENN domain containing 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3548
See related: Ensembl:ENSDARG00000062965 AllianceGenome:ZFIN:ZDB-GENE-030131-3548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fam45a; wu:fc44d12; wu:fd19e06; si:ch211-117n7.2
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Predicted to be located in endosome. Predicted to be active in late endosome. Orthologous to several human genes including DENND10 (DENN domain containing 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (9819135..9830710)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (9487125..9498687)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd19e06.x1 (e-PCR)
- UniSTS:204246

fc44d12 (e-PCR)
- UniSTS:189167

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endosome transport via multivesicular body sorting pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of early endosome to late endosome transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DENN domain-containing protein 10

Names: family with sequence similarity 45 member A; protein FAM45A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167661.1 → NP_001161133.1 DENN domain-containing protein 10

Status: VALIDATED

Source sequence(s)

BC154508, BX248127

UniProtKB/Swiss-Prot

A8E7G4, A8WFY8

Related

ENSDARP00000086028.4, ENSDART00000091595.6

Conserved Domains (1) summary

pfam08616
Location:153 → 259

SPA; Stabilization of polarity axis