psmb4 proteasome 20S subunit beta 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: psmb4provided by ZNC
Official Full Name: proteasome 20S subunit beta 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-333
See related: Ensembl:ENSDARG00000054696 AllianceGenome:ZFIN:ZDB-GENE-050417-333
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6909492; zgc:110330
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within proteolysis involved in protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 3. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (42456922..42462440, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (42887485..42893049, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteasome subunit beta type-4

Names: proteasome (prosome, macropain) subunit, beta type, 4; proteasome subunit beta 4

NP_001017801.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017801.1 → NP_001017801.1 proteasome subunit beta type-4

See identical proteins and their annotated locations for NP_001017801.1

Status: PROVISIONAL

Source sequence(s)

BC092880

UniProtKB/TrEMBL

A0A8M2B6L9, A8E7N8, Q568F3

Related

ENSDARP00000117990.1, ENSDART00000131715.2

Conserved Domains (2) summary

COG0638
Location:3 → 192

PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]

cd03760
Location:3 → 198

proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...