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    dclk1a doublecortin-like kinase 1a [ Danio rerio (zebrafish) ]

    Gene ID: 558997, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dclk1aprovided by ZNC
    Official Full Name
    doublecortin-like kinase 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-124
    See related
    Ensembl:ENSDARG00000018856 AllianceGenome:ZFIN:ZDB-GENE-061013-124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dclk1; dcamkl1; wu:fc51f11; zgc:153709
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in axon extension and protein localization to nucleus. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human DCLK1 (doublecortin like kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See dclk1a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (34737317..34871706, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (34793460..34928099, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene StAR related lipid transfer domain containing 13a Neighboring gene neurobeachin a Neighboring gene coiled-coil domain containing 169 Neighboring gene spartin a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Influence of Ser/Pro-rich domain and kinase domain of double cortin-like protein kinase on microtubule-binding activity. Nagamine T, et al. J Biochem, 2011 May. PMID 21278387
    2. Expression, characterization, and gene knockdown of zebrafish doublecortin-like protein kinase. Shimomura S, et al. Arch Biochem Biophys, 2007 Jul 15. PMID 17498644
    3. New age-related hearing loss candidate genes in humans: an ongoing challenge. Di Stazio M, et al. Gene, 2020 Jun 5. PMID 32173538
    4. Identification of an endogenous substrate of zebrafish doublecortin-like protein kinase using a highly active truncation mutant. Shimomura S, et al. J Biochem, 2010 May. PMID 20097902
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that both the kinase domain and the Ser/Pro-rich domain are involved in regulating the microtubule-binding activity of doublecortin-like protein kinase (DCLK).
      Title: Influence of Ser/Pro-rich domain and kinase domain of double cortin-like protein kinase on microtubule-binding activity.
    2. DCLK mediates its neuronal functions through phosphorylation of physiological substrates such as synapsin II
      Title: Identification of an endogenous substrate of zebrafish doublecortin-like protein kinase using a highly active truncation mutant.
    3. Gene knockdown studies of zDCLK suggest that zDCLK may play crucial roles in the central nervous systems during the early stage of embryogenesis.
      Title: Expression, characterization, and gene knockdown of zebrafish doublecortin-like protein kinase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153709

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase DCLK1a
    Names
    doublecortin and CaM kinase-like 1
    doublecortin and calcium/calmodulin-dependent protein kinase-like 1
    doublecortin-like kinase 1
    NP_001071017.1
    XP_005172728.1
    XP_009303718.1
    XP_009303720.1
    XP_021334856.1
    XP_068079903.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077549.2 → NP_001071017.1  serine/threonine-protein kinase DCLK1a

      Status: VALIDATED

      Source sequence(s)
      BX248233, EH432532
      UniProtKB/TrEMBL
      A0A8N7XJI7, B2GSP8, F1R5D1, Q08BH4
      Related
      ENSDARP00000121156.2, ENSDART00000145450.3
      Conserved Domains (2) summary
      smart00220
      Location:85 → 342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14183
      Location:78 → 345
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      34737317..34871706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172671.5 → XP_005172728.1  serine/threonine-protein kinase DCLK1a isoform X1

      UniProtKB/TrEMBL
      A0A0R4IZ94, A0A8M3BD62, E9QBD0
      Related
      ENSDARP00000116522.2, ENSDART00000138755.3
      Conserved Domains (3) summary
      smart00220
      Location:383 → 640
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:46 → 137
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:376 → 643
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

    2. XM_009305445.4 → XP_009303720.1  serine/threonine-protein kinase DCLK1a isoform X2

      UniProtKB/TrEMBL
      A0A8M3AWX7
      Conserved Domains (3) summary
      smart00220
      Location:383 → 640
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:46 → 137
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:376 → 643
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

    3. XM_009305443.4 → XP_009303718.1  serine/threonine-protein kinase DCLK1a isoform X1

      UniProtKB/TrEMBL
      A0A0R4IZ94, A0A8M3BD62, E9QBD0
      Conserved Domains (3) summary
      smart00220
      Location:383 → 640
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:46 → 137
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:376 → 643
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

    4. XM_021479181.2 → XP_021334856.1  serine/threonine-protein kinase DCLK1a isoform X3

      UniProtKB/TrEMBL
      A0A8M9QGM9
      Conserved Domains (1) summary
      smart00537
      Location:46 → 137
      DCX; Domain in the Doublecortin (DCX) gene product

    5. XM_068223802.1 → XP_068079903.1  serine/threonine-protein kinase DCLK1a isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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