firrm fignl1 interacting regulator of recombination and mitosis [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: firrmprovided by ZNC
Official Full Name: fignl1 interacting regulator of recombination and mitosisprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3554
See related: Ensembl:ENSDARG00000042120 AllianceGenome:ZFIN:ZDB-GENE-030131-3554
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: FLIP; fc44g01; wu:fc44g01; zgc:110228; si:dkey-97o5.1
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in interstrand cross-link repair and mitotic cell cycle. Predicted to be located in several cellular components, including kinetochore; midbody; and spindle midzone. Orthologous to human FIRRM (FIGNL1 interacting regulator of recombination and mitosis). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (33994732..34010235)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (34090923..34107409)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc44g01.x1 (e-PCR)
- UniSTS:188179

fe36g10.y1 (e-PCR)
- UniSTS:196405

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in interstrand cross-link repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: FIGNL1-interacting regulator of recombination and mitosis

Names: FIDGETIN-like-1 interacting protein; POLO1-associating protein; uncharacterized protein C1orf112 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020659.2 → NP_001018495.1 FIGNL1-interacting regulator of recombination and mitosis

See identical proteins and their annotated locations for NP_001018495.1

Status: PROVISIONAL

Source sequence(s)

BC095206

UniProtKB/Swiss-Prot

Q5TYP4

Related

ENSDARP00000061728.5, ENSDART00000061729.7

Conserved Domains (1) summary

pfam14868
Location:226 → 779

DUF4487; Domain of unknown function (DUF4487)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

33994732..34010235

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160693.5 → XP_005160750.1 FIGNL1-interacting regulator of recombination and mitosis isoform X1

See identical proteins and their annotated locations for XP_005160750.1

UniProtKB/Swiss-Prot

Q503S2, Q5TYP4

Conserved Domains (1) summary

pfam14868
Location:226 → 779

DUF4487; Domain of unknown function (DUF4487)