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    pkn2a protein kinase N2a [ Danio rerio (zebrafish) ]

    Gene ID: 571965, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pkn2aprovided by ZNC
    Official Full Name
    protein kinase N2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061207-42
    See related
    Ensembl:ENSDARG00000101983 AllianceGenome:ZFIN:ZDB-GENE-061207-42
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pkn2; wu:fa97c07; si:ch211-83f14.1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within embryonic viscerocranium morphogenesis and heart development. Predicted to be located in several cellular components, including cleavage furrow; midbody; and nucleus. Orthologous to human PKN2 (protein kinase N2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See pkn2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (22416866..22479547)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (22761144..22824263)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene heparan sulfate 2-O-sulfotransferase 1a Neighboring gene zgc:56628 Neighboring gene general transcription factor IIB Neighboring gene leucine rich repeat containing 8 VRAC subunit Da

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Large-scale discovery of novel genetic causes of developmental disorders. Deciphering Developmental Disorders Study. Nature, 2015 Mar 12. PMID 25533962, Free PMC Article
    2. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase N2; serine/threonine-protein kinase N2-like
    Names
    protein kinase N2
    XP_700704.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      22416866..22479547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_695612.10 → XP_700704.3  serine/threonine-protein kinase N2-like

      UniProtKB/TrEMBL
      A0A0R4IJZ0, A0A8N7T8C2
      Related
      ENSDARP00000134148.1, ENSDART00000172715.2
      Conserved Domains (5) summary
      cd08687
      Location:387 → 468
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:29 → 94
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      smart00220
      Location:643 → 902
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05589
      Location:643 → 968
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:116 → 189
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    Nucleotide Protein
    Heading Accession and Version

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