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    sfswap splicing factor SWAP [ Danio rerio (zebrafish) ]

    Gene ID: 394143, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sfswapprovided by ZNC
    Official Full Name
    splicing factor SWAPprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-931
    See related
    Ensembl:ENSDARG00000005980 AllianceGenome:ZFIN:ZDB-GENE-040426-931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sfrs8; srsf8; zgc:56184
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA 5'-splice site recognition. Predicted to act upstream of or within RNA processing. Orthologous to human SFSWAP (splicing factor SWAP). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sfswap in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (15125497..15282452, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (15029032..15186475, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909433 Neighboring gene unc-51 like autophagy activating kinase 1 Neighboring gene matrix metallopeptidase 17a Neighboring gene si:dkey-11o15.4 Neighboring gene si:dkey-11o15.5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
    2. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC56184

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 5'-splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor, suppressor of white-apricot homolog
    Names
    serine/arginine-rich splicing factor 8
    splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila)
    splicing factor, suppressor of white-apricot family

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201168.2 → NP_957462.2  splicing factor, suppressor of white-apricot homolog

      Status: VALIDATED

      Source sequence(s)
      BX901878, CR762410
      UniProtKB/TrEMBL
      A0A8N7V040, F1Q5L3
      Related
      ENSDARP00000121684.1, ENSDART00000143113.3
      Conserved Domains (3) summary
      smart00648
      Location:197 → 250
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam09750
      Location:27 → 143
      DRY_EERY; Alternative splicing regulator
      cl00583
      Location:605 → 698
      PhaG_MnhG_YufB; Na+/H+ antiporter subunit

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      15125497..15282452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009295295.4 → XP_009293570.1  splicing factor, suppressor of white-apricot homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M3B4N2
      Conserved Domains (3) summary
      smart00648
      Location:197 → 250
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam09750
      Location:27 → 143
      DRY_EERY; Alternative splicing regulator
      cl00583
      Location:605 → 698
      PhaG_MnhG_YufB; Na+/H+ antiporter subunit

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395081.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      2276..32358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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