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    eral1 Era-like 12S mitochondrial rRNA chaperone 1 [ Danio rerio (zebrafish) ]

    Gene ID: 569087, updated on 4-Jan-2025

    Summary

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    Official Symbol
    eral1provided by ZNC
    Official Full Name
    Era-like 12S mitochondrial rRNA chaperone 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-84
    See related
    Ensembl:ENSDARG00000059887 AllianceGenome:ZFIN:ZDB-GENE-060526-84
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-207c6.1
    Summary
    Predicted to enable rRNA binding activity and ribosomal small subunit binding activity. Predicted to be involved in ribosomal small subunit assembly. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in Perrault syndrome 6. Orthologous to human ERAL1 (Era like 12S mitochondrial rRNA chaperone 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See eral1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (42259024..42270084)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (41658871..41669931)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily V, member 1 Neighboring gene family with sequence similarity 222 member Ba Neighboring gene uncharacterized LOC137495623 Neighboring gene microRNA 451a Neighboring gene microRNA 144

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Experimental validation and complexity of miRNA-mRNA target interaction during zebrafish primitive erythropoiesis. Du TT, et al. Biochem Biophys Res Commun, 2009 Apr 17. PMID 19254693
    2. Genomic conservation of erythropoietic microRNAs (erythromiRs) in white-blooded Antarctic icefish. Desvignes T, et al. Mar Genomics, 2016 Dec. PMID 27189439, Free PMC Article
    3. Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis. Fu YF, et al. Blood, 2009 Feb 5. PMID 18941117
    4. Evolution of the tbx6/16 subfamily genes in vertebrates: insights from zebrafish. Ahn D, et al. Mol Biol Evol, 2012 Dec. PMID 22915831
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase Era, mitochondrial
    Names
    ERA-like protein 1
    Era G-protein-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128747.1 → NP_001122219.1  GTPase Era, mitochondrial

      See identical proteins and their annotated locations for NP_001122219.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163468
      UniProtKB/Swiss-Prot
      B0S6U7
      Related
      ENSDARP00000078213.4, ENSDART00000083778.5
      Conserved Domains (3) summary
      cd04163
      Location:109 → 255
      Era; E. coli Ras-like protein (Era) is a multifunctional GTPase
      COG1159
      Location:105 → 447
      Era; GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]
      pfam07650
      Location:373 → 447
      KH_2; KH domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      42259024..42270084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0S6U7.1 GenPept UniProtKB/Swiss-Prot:B0S6U7

    Gene LinkOut

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