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    toporsa topoisomerase I binding, arginine/serine-rich a [ Danio rerio (zebrafish) ]

    Gene ID: 324197, updated on 4-Jan-2025

    Summary

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    Official Symbol
    toporsaprovided by ZNC
    Official Full Name
    topoisomerase I binding, arginine/serine-rich aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6401
    See related
    Ensembl:ENSDARG00000037260 AllianceGenome:ZFIN:ZDB-GENE-030131-6401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    topors; wu:fc21e07; si:ch211-145b13.4
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within retina layer formation. Is expressed in photoreceptor inner segment layer; retinal ganglion cell layer; retinal inner nuclear layer; and retinal outer nuclear layer. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See toporsa in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26105131..26109961)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (25411414..25416247)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene MAX dimerization protein 4 Neighboring gene NADH:ubiquinone oxidoreductase subunit B Neighboring gene methylthioadenosine phosphorylase Neighboring gene cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein. Chakarova CF, et al. Hum Mol Genet, 2011 Mar 1. PMID 21159800, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    topoisomerase I binding, arginine/serine-rich a
    NP_001292484.1
    XP_021334958.1
    XP_068079696.1
    XP_068079729.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305555.1 → NP_001292484.1  topoisomerase I binding, arginine/serine-rich a

      Status: VALIDATED

      Source sequence(s)
      BX323448, EH593328
      UniProtKB/TrEMBL
      A0A8M1P6B6, E7EXN7, E7F1A2, F6N9Q9
      Related
      ENSDARP00000093155.4, ENSDART00000102379.5
      Conserved Domains (2) summary
      cd16574
      Location:28 → 67
      RING-HC_Topors; RING finger, HC subclass, found in topoisomerase I-binding arginine/serine-rich protein (Topors) and similar proteins
      cl25887
      Location:635 → 749
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      26105131..26109961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479283.2 → XP_021334958.1  topoisomerase I binding, arginine/serine-rich a isoform X1

      UniProtKB/TrEMBL
      A0A8M1P6B6, E7EXN7, E7F1A2, F6N9Q9
      Conserved Domains (2) summary
      cd16574
      Location:28 → 67
      RING-HC_Topors; RING finger, HC subclass, found in topoisomerase I-binding arginine/serine-rich protein (Topors) and similar proteins
      cl25887
      Location:635 → 749
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    2. XM_068223628.1 → XP_068079729.1  topoisomerase I binding, arginine/serine-rich a isoform X3

    3. XM_068223595.1 → XP_068079696.1  topoisomerase I binding, arginine/serine-rich a isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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