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    kcnab1a potassium voltage-gated channel subfamily A regulatory beta subunit 1a [ Danio rerio (zebrafish) ]

    Gene ID: 541540, updated on 4-Jan-2025

    Summary

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    Official Symbol
    kcnab1aprovided by ZNC
    Official Full Name
    potassium voltage-gated channel subfamily A regulatory beta subunit 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050327-79
    See related
    Ensembl:ENSDARG00000008140 AllianceGenome:ZFIN:ZDB-GENE-050327-79
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    kcnab1; zgc:113627
    Summary
    Predicted to enable oxidoreductase activity and voltage-gated potassium channel activity. Predicted to act upstream of or within monoatomic ion transmembrane transport and potassium ion transport. Predicted to be located in cytoplasm and plasma membrane. Is expressed in several structures, including heart; immature eye; myotome; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See kcnab1a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (34290466..34539842)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (34386584..34559550)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene guanine monophosphate synthase Neighboring gene vomeronasal 2, receptor 1 Neighboring gene uncharacterized LOC103909167 Neighboring gene signal sequence receptor, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Coexpression of auxiliary Kvβ2 subunits with Kv1.1 channels is required for developmental acquisition of unique firing properties of zebrafish Mauthner cells. Watanabe T, et al. J Neurophysiol, 2014 Mar. PMID 24335214
    2. Structure-based developmental toxicity and ASD-phenotypes of bisphenol A analogues in embryonic zebrafish. Bai C, et al. Ecotoxicol Environ Saf, 2023 Mar 15. PMID 36805134
    3. Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5-cryab-hspb2 signalling in zebrafish. Gou D, et al. Acta Physiol (Oxf), 2021 Mar. PMID 33032360
    4. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Prendergast AE, et al. Curr Biol, 2023 Mar 13. PMID 36791723
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated potassium channel subunit beta-1a
    Names
    potassium voltage-gated channel, shaker-related subfamily, beta member 1 a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014354.1 → NP_001014376.1  voltage-gated potassium channel subunit beta-1a

      See identical proteins and their annotated locations for NP_001014376.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091978
      UniProtKB/TrEMBL
      A0A8M1N4N5, Q58EC4
      Related
      ENSDARP00000122075.1, ENSDART00000131478.3
      Conserved Domains (2) summary
      cd06660
      Location:70 → 385
      Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
      TIGR01293
      Location:70 → 386
      Kv_beta; voltage-dependent potassium channel beta subunit, animal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      34290466..34539842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467646.2 → XP_021323321.1  voltage-gated potassium channel subunit beta-1a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PM35
      Conserved Domains (1) summary
      TIGR01293
      Location:90 → 390
      Kv_beta; voltage-dependent potassium channel beta subunit, animal

    2. XM_021467647.2 → XP_021323322.1  voltage-gated potassium channel subunit beta-1a isoform X2

      UniProtKB/TrEMBL
      A0A8M9P126
      Conserved Domains (1) summary
      TIGR01293
      Location:90 → 406
      Kv_beta; voltage-dependent potassium channel beta subunit, animal

    3. XM_021467649.2 → XP_021323324.1  voltage-gated potassium channel subunit beta-1a isoform X4

      UniProtKB/TrEMBL
      A0A8M9PFF1
      Conserved Domains (1) summary
      TIGR01293
      Location:78 → 394
      Kv_beta; voltage-dependent potassium channel beta subunit, animal

    4. XM_021467648.2 → XP_021323323.1  voltage-gated potassium channel subunit beta-1a isoform X3

      UniProtKB/TrEMBL
      A0A8M9PA23
      Conserved Domains (1) summary
      TIGR01293
      Location:78 → 378
      Kv_beta; voltage-dependent potassium channel beta subunit, animal

    5. XM_068214764.1 → XP_068070865.1  voltage-gated potassium channel subunit beta-1a isoform X6

    6. XM_021467650.2 → XP_021323325.1  voltage-gated potassium channel subunit beta-1a isoform X5

      UniProtKB/TrEMBL
      A0A8M9PQ73
      Conserved Domains (1) summary
      TIGR01293
      Location:70 → 370
      Kv_beta; voltage-dependent potassium channel beta subunit, animal

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395036.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      31680..130916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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