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    znf710a zinc finger protein 710a [ Danio rerio (zebrafish) ]

    Gene ID: 327348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    znf710aprovided by ZNC
    Official Full Name
    zinc finger protein 710aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5559
    See related
    Ensembl:ENSDARG00000014680 AllianceGenome:ZFIN:ZDB-GENE-030131-5559
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi04b07; zgc:66441; wu:fi04b07
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in central nervous system; ectoderm; neural plate; vein; and ventral mesoderm. Orthologous to human ZNF710 (zinc finger protein 710). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See znf710a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (26048122..26096772)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (26061596..26110717)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 2a Neighboring gene RAS and EF-hand domain containing 2 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ba Neighboring gene isocitrate dehydrogenase (NADP(+)) 2 Neighboring gene ankyrin repeat domain 34C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transgenic IDH2(R172K) and IDH2(R140Q) zebrafish models recapitulated features of human acute myeloid leukemia. Wang D, et al. Oncogene, 2023 Apr. PMID 36739363, Free PMC Article
    2. Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Huo X, et al. Sci Rep, 2019 Feb 6. PMID 30728369, Free PMC Article
    3. Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Shi X, et al. Blood, 2015 May 7. PMID 25778530
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 710a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199792.1 → NP_956086.1  zinc finger protein 710a

      See identical proteins and their annotated locations for NP_956086.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054704
      UniProtKB/TrEMBL
      Q7SYJ4
      Related
      ENSDARP00000024217.9, ENSDART00000015712.10
      Conserved Domains (4) summary
      COG5048
      Location:334 → 575
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:463 → 485
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:572 → 596
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      26048122..26096772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214726.1 → XP_068070827.1  zinc finger protein 710a isoform X3

    2. XM_005159166.5 → XP_005159223.1  zinc finger protein 710a isoform X1

      UniProtKB/TrEMBL
      A0A2R8RWY8, A0A8M2B631
      Related
      ENSDARP00000154948.1, ENSDART00000187911.1
      Conserved Domains (4) summary
      COG5048
      Location:348 → 589
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:477 → 499
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:586 → 610
      zf-H2C2_2; Zinc-finger double domain

    3. XM_005159167.5 → XP_005159224.1  zinc finger protein 710a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B5R8
      Conserved Domains (4) summary
      COG5048
      Location:348 → 579
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:477 → 499
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:576 → 600
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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