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    cicb capicua transcriptional repressor b [ Danio rerio (zebrafish) ]

    Gene ID: 323246, updated on 4-Jan-2025

    Summary

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    Official Symbol
    cicbprovided by ZNC
    Official Full Name
    capicua transcriptional repressor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1966
    See related
    Ensembl:ENSDARG00000055502 AllianceGenome:ZFIN:ZDB-GENE-030131-1966
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cic; wu:fb93c01
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within primitive erythrocyte differentiation. Predicted to be located in nucleus. Is expressed in head and hindbrain neural rod. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 45. Orthologous to human CIC (capicua transcriptional repressor). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See cicb in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (11166966..11222833)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (11260815..11331893)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene POU class 2 homeobox 2b Neighboring gene Ets2 repressor factor like 3 Neighboring gene zinc finger protein 526 Neighboring gene glycogen synthase kinase 3 alpha b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of Bbx, a member of a novel subfamily of the HMG-box superfamily together with Cic. Chen T, et al. Dev Genes Evol, 2014 Dec. PMID 25079045
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within primitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    capicua transcriptional repressor b; protein capicua homolog
    Names
    capicua homolog b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      11166966..11222833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173512.5 → XP_005173569.2  protein capicua homolog isoform X1

      UniProtKB/TrEMBL
      A0A8M2BKS3

    2. XM_002664811.7 → XP_002664857.3  protein capicua homolog isoform X2

      UniProtKB/TrEMBL
      A0A8M1RE21, F1Q6M9
      Related
      ENSDARP00000115789.2, ENSDART00000140674.3

    3. XM_005173513.5 → XP_005173570.1  protein capicua homolog isoform X3

      UniProtKB/TrEMBL
      A0A8M2BKS2
      Conserved Domains (1) summary
      cd01388
      Location:161 → 232
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    4. XM_068214094.1 → XP_068070195.1  protein capicua homolog isoform X4

      Related
      ENSDARP00000150349.1, ENSDART00000186011.1
    Nucleotide Protein Strain
    Heading Accession and Version

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