mtus1a microtubule associated tumor suppressor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mtus1aprovided by ZNC
Official Full Name: microtubule associated tumor suppressor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061103-409
See related: Ensembl:ENSDARG00000071562 AllianceGenome:ZFIN:ZDB-GENE-061103-409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa17d11; wu:fa17d11; wu:fi18f08; zgc:154168
Summary: Predicted to enable microtubule binding activity. Predicted to be located in Golgi apparatus; mitochondrion; and plasma membrane. Predicted to be active in nucleus. Predicted to colocalize with cytoplasm. Is expressed in blastodisc and female organism. Orthologous to human MTUS1 (microtubule associated scaffold protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (30285647..30357472)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (29945341..30017158)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
colocalizes_with cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated tumor suppressor 1 homolog A

Names: mitochondrial tumor suppressor 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077608.2 → NP_001071076.2 microtubule-associated tumor suppressor 1 homolog A

Status: VALIDATED

Source sequence(s)

BC125970, CR384105, CT955983

UniProtKB/Swiss-Prot

A0JMQ7

UniProtKB/TrEMBL

F1R2R1

Related

ENSDARP00000096667.3, ENSDART00000105889.5

Conserved Domains (2) summary

pfam06364
Location:125 → 218

DUF1068; Protein of unknown function (DUF1068)

cl00173
Location:185 → 405

VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

30285647..30357472

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068213221.1 → XP_068069322.1 microtubule-associated tumor suppressor 1 homolog A isoform X1

UniProtKB/TrEMBL

A0A140LH04, A0A8M2B3D7

Related

ENSDARP00000142534.1, ENSDART00000173090.2
XM_068213222.1 → XP_068069323.1 microtubule-associated tumor suppressor 1 homolog A isoform X2

UniProtKB/TrEMBL

A0A8M6Z222
XM_005157240.5 → XP_005157297.1 microtubule-associated tumor suppressor 1 homolog A isoform X1

See identical proteins and their annotated locations for XP_005157297.1

UniProtKB/TrEMBL

A0A140LH04, A0A8M2B3D7

Conserved Domains (3) summary

pfam01442
Location:787 → 999

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl00173
Location:857 → 1087

VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

cl12013
Location:752 → 936

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_068213223.1 → XP_068069324.1 microtubule-associated tumor suppressor 1 homolog A isoform X3

UniProtKB/Swiss-Prot

A0JMQ7