U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [ Danio rerio (zebrafish) ]

    Gene ID: 100034522, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    mthfd1lprovided by ZNC
    Official Full Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041001-133
    See related
    Ensembl:ENSDARG00000042221 AllianceGenome:ZFIN:ZDB-GENE-041001-133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk48e08; wu:fk48e08; si:dkey-25e12.5; si:dkey-25e12.6
    Summary
    Predicted to enable formate-tetrahydrofolate ligase activity. Predicted to be involved in 10-formyltetrahydrofolate biosynthetic process. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in cytosol. Is expressed in anterior neural tube and optic cup. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mthfd1l in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (26478197..26531854, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (26579100..26632809, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 2b Neighboring gene A kinase (PRKA) anchor protein 12b Neighboring gene uncharacterized LOC137488653 Neighboring gene syntaxin 11b, tandem duplicate 2 Neighboring gene syntaxin 11b, tandem duplicate 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics. Zhang XY, et al. Pharmaceuticals (Basel), 2021 Jul 11. PMID 34358088, Free PMC Article
    2. The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects. Hsiao TH, et al. Front Cell Dev Biol, 2021. PMID 34268314, Free PMC Article
    3. Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish. Lee Y, et al. FASEB J, 2020 Jan. PMID 31914627
    4. Disruption of the folate pathway in zebrafish causes developmental defects. Lee MS, et al. BMC Dev Biol, 2012 Apr 5. PMID 22480165, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formate-tetrahydrofolate ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 10-formyltetrahydrofolate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    monofunctional C1-tetrahydrofolate synthase, mitochondrial
    NP_001229925.1
    XP_005160608.1
    XP_005160609.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242996.1 → NP_001229925.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial

      See identical proteins and their annotated locations for NP_001229925.1

      Status: VALIDATED

      Source sequence(s)
      BX537272
      UniProtKB/TrEMBL
      A0A8M1P3W3, F1QQ79
      Related
      ENSDARP00000154669.1, ENSDART00000183317.1
      Conserved Domains (4) summary
      PLN02759
      Location:352 → 978
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:81 → 336
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:80 → 183
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      cl21454
      Location:196 → 335
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      26478197..26531854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160551.5 → XP_005160608.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005160608.1

      UniProtKB/TrEMBL
      A0A8M1P3W3, F1QQ79
      Conserved Domains (4) summary
      PLN02759
      Location:352 → 978
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:81 → 336
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:80 → 183
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      cl21454
      Location:196 → 335
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_005160552.5 → XP_005160609.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005160609.1

      UniProtKB/TrEMBL
      A0A8M1P3W3, F1QQ79
      Related
      ENSDARP00000061913.4, ENSDART00000061914.7
      Conserved Domains (4) summary
      PLN02759
      Location:352 → 978
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:81 → 336
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:80 → 183
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      cl21454
      Location:196 → 335
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395074.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      568697..632558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.