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    tns2b tensin 2b [ Danio rerio (zebrafish) ]

    Gene ID: 565809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tns2bprovided by ZNC
    Official Full Name
    tensin 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-101001-5
    See related
    Ensembl:ENSDARG00000068397 AllianceGenome:ZFIN:ZDB-GENE-101001-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tenc1b; fc15a01; wu:fc15a01; si:ch211-71p22.1
    Summary
    Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be located in focal adhesion. Orthologous to human TNS2 (tensin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tns2b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (39013905..39050997, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (39016367..39053827, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene vitamin D receptor b Neighboring gene transfer RNA glutamine (anticodon UUG) Neighboring gene uncharacterized LOC137495994 Neighboring gene eukaryotic translation initiation factor 4Bb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tensin 2b; tensin-2
    Names
    tensin like C1 domain containing phosphatase b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      39013905..39050997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166088.5 → XP_005166145.1  tensin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BDF7
      Conserved Domains (5) summary
      cd09927
      Location:1168 → 1283
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:191 → 304
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:1307 → 1428
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam00130
      Location:45 → 91
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam10409
      Location:293 → 420
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    2. XM_689077.10 → XP_694169.6  tensin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8N7UT94
      Related
      ENSDARP00000089676.4, ENSDART00000098906.5
      Conserved Domains (5) summary
      cd09927
      Location:1168 → 1283
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:191 → 304
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:1307 → 1438
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam00130
      Location:45 → 91
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam10409
      Location:293 → 420
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394660.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      117735..155372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471814.2 → XP_021327489.1  tensin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PRI6
      Conserved Domains (5) summary
      cd09927
      Location:1168 → 1283
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:191 → 304
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:1307 → 1428
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam00130
      Location:45 → 91
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam10409
      Location:293 → 420
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    2. XM_021471813.2 → XP_021327488.1  tensin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PKG9
      Conserved Domains (5) summary
      cd09927
      Location:1168 → 1283
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:191 → 304
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:1307 → 1438
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam00130
      Location:45 → 91
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam10409
      Location:293 → 420
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    Nucleotide Protein Strain
    Heading Accession and Version

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