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    phf12a PHD finger protein 12a [ Danio rerio (zebrafish) ]

    Gene ID: 562152, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phf12aprovided by ZNC
    Official Full Name
    PHD finger protein 12aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3876
    See related
    Ensembl:ENSDARG00000074303 AllianceGenome:ZFIN:ZDB-GENE-030131-3876
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc56f04; wu:fc56f04; wu:cegs2807
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of Sin3-type complex. Predicted to be active in nucleus. Orthologous to human PHF12 (PHD finger protein 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See phf12a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (36811371..36825984, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (36867630..36882548, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 2 Neighboring gene dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 1 Neighboring gene seizure related 6 homolog a Neighboring gene myosin XVIIIAa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      36811371..36825984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001919920.8 → XP_001919955.4  PHD finger protein 12

      UniProtKB/TrEMBL
      A0A8M1QUR4, E7EXI6
      Related
      ENSDARP00000098593.2, ENSDART00000111104.5
      Conserved Domains (5) summary
      cd00060
      Location:744 → 797
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15533
      Location:59 → 102
      PHD1_PHF12; PHD finger 1 found in PHD finger protein 12 (PHF12)
      cd15534
      Location:284 → 329
      PHD2_PHF12_Rco1; PHD finger 2 found in PHD finger protein 12 (PHF12), yeast Rco1, and similar proteins
      pfam16737
      Location:214 → 252
      PHF12_MRG_bd; PHD finger protein 12 MRG binding domain
      cl02608
      Location:78 → 140
      BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
    Nucleotide Protein Strain
    Heading Accession and Version

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