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    ahcyl1 adenosylhomocysteinase-like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 798918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ahcyl1provided by ZNC
    Official Full Name
    adenosylhomocysteinase-like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021206-7
    See related
    Ensembl:ENSDARG00000056331 AllianceGenome:ZFIN:ZDB-GENE-021206-7
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb586; wu:fj66f02
    Summary
    Predicted to enable adenosylhomocysteinase activity. Acts upstream of or within dorsal/ventral pattern formation. Predicted to be active in cytosol. Is expressed in several structures, including hatching gland; nervous system; pectoral fin musculature; polster; and pronephric duct. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ahcyl1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (24971889..25011170, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (24952750..24991967, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shaw-related subfamily, member 4 Neighboring gene heat shock protein family A (Hsp70) member 1B Neighboring gene nuclear transcription factor Y, alpha, like Neighboring gene neugrin, neurite outgrowth associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. AHCYL1 is mediated by estrogen-induced ERK1/2 MAPK cell signaling and microRNA regulation to effect functional aspects of the avian oviduct. Jeong W, et al. PLoS One, 2012. PMID 23145124, Free PMC Article
    2. Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. Cooper BJ, et al. J Biol Chem, 2006 Aug 11. PMID 16754674
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AHCYL1 has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release
      Title: Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64088

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    NOT enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosylhomocysteinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosylhomocysteine hydrolase-like protein 1
    Names
    S-adenosylhomocysteine hydrolase-like 1
    NP_001417990.1
    NP_958450.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431061.1 → NP_001417990.1  S-adenosylhomocysteine hydrolase-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX470135
      UniProtKB/TrEMBL
      A0A8M2BEI8, A5PMG3, Q7T2B5
      Related
      ENSDARP00000073253.4, ENSDART00000078792.5

    2. NM_201293.2 → NP_958450.2  S-adenosylhomocysteine hydrolase-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      BX470135
      UniProtKB/TrEMBL
      Q7T2B5
      Related
      ENSDARP00000073256.4, ENSDART00000078795.6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      24971889..25011170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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