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    pnp4a purine nucleoside phosphorylase 4a [ Danio rerio (zebrafish) ]

    Gene ID: 415192, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pnp4aprovided by ZNC
    Official Full Name
    purine nucleoside phosphorylase 4aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040625-83
    See related
    Ensembl:ENSDARG00000057575 AllianceGenome:ZFIN:ZDB-GENE-040625-83
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zK76P14.1; zgc:86889
    Summary
    Predicted to enable purine-nucleoside phosphorylase activity. Predicted to act upstream of or within purine ribonucleoside salvage. Predicted to be active in cytoplasm. Is expressed in several structures, including eye; integument; iridoblast; neural crest; and optic vesicle. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See pnp4a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (24290130..24297701)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (24052514..24060085)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886364 Neighboring gene SRY-box transcription factor 12 Neighboring gene si:dkey-76p14.2 Neighboring gene RAS (RAD and GEM)-like GTP-binding 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Protein Kinase A Signaling Inhibits Iridophore Differentiation in Zebrafish. Cooper CD, et al. J Dev Biol, 2018 Sep 26. PMID 30261583, Free PMC Article
    2. Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish. Clancey LF, et al. PLoS One, 2013. PMID 23724125, Free PMC Article
    3. Nicastrin Deficiency Induces Tyrosinase-Dependent Depigmentation and Skin Inflammation. Hsu CH, et al. J Invest Dermatol, 2020 Feb. PMID 31437444
    4. Endothelin signalling in iridophore development and stripe pattern formation of zebrafish. Krauss J, et al. Biol Open, 2014 May 23. PMID 24857848, Free PMC Article
    5. A macrophage relay for long-distance signaling during postembryonic tissue remodeling. Eom DS, et al. Science, 2017 Mar 24. PMID 28209639, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-nucleoside phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    purine nucleoside phosphorylase 4a
    NP_001002102.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002102.1 → NP_001002102.1  purine nucleoside phosphorylase 4a

      See identical proteins and their annotated locations for NP_001002102.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071515
      UniProtKB/TrEMBL
      A0A8M1N013, Q6IQ95, Q7SZW5
      Related
      ENSDARP00000032177.4, ENSDART00000029695.5
      Conserved Domains (2) summary
      COG0005
      Location:13 → 284
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      PRK08202
      Location:9 → 284
      PRK08202; purine nucleoside phosphorylase; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      24290130..24297701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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