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    dlx2a distal-less homeobox 2a [ Danio rerio (zebrafish) ]

    Gene ID: 30574, updated on 22-Dec-2024

    Summary

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    Official Symbol
    dlx2aprovided by ZNC
    Official Full Name
    distal-less homeobox 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-212
    See related
    Ensembl:ENSDARG00000079964 AllianceGenome:ZFIN:ZDB-GENE-980526-212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dlx2; dlx-2; zgc:110518
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neural crest cell development; pharyngeal system development; and skeletal system development. Predicted to be located in nucleus. Is expressed in several structures, including brain; cranial cartilage; neural crest; pectoral fin bud; and pharyngeal arch. Orthologous to human DLX2 (distal-less homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dlx2a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (3397407..3400729, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (3425878..3429200, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase 1 Neighboring gene uncharacterized LOC137496440 Neighboring gene distal-less homeobox 1a Neighboring gene integrin, alpha 6a Neighboring gene cytochrome b reductase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The chinless mutation and neural crest cell interactions in zebrafish jaw development. Schilling TF, et al. Development, 1996 May. PMID 8625830
    2. Comparison of solvate ionic liquids and DMSO as an in vivo delivery and storage media for small molecular therapeutics. Yoganantharajah P, et al. BMC Biotechnol, 2018 May 29. PMID 29843701, Free PMC Article
    3. Functional conservation of a forebrain enhancer from the elephant shark (Callorhinchus milii ) in zebrafish and mice. MacDonald RB, et al. BMC Evol Biol, 2010 May 26. PMID 20504318, Free PMC Article
    4. Contributions of developmental studies in the dogfish Scyliorhinus canicula to the brain anatomy of elasmobranchs: insights on the basal ganglia. Quintana-Urzainqui I, et al. Brain Behav Evol, 2012. PMID 22986828
    5. Macondo crude oil from the Deepwater Horizon oil spill disrupts specific developmental processes during zebrafish embryogenesis. de Soysa TY, et al. BMC Biol, 2012 May 4. PMID 22559716, Free PMC Article

    See all (404) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that dlx1a/2a and dlx5a/6a expressing progenitors give rise, for the most part, to small populations of cells which constitute only a small proportion of GABAergic cells in the adult brain tissue.
      Title: Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain.
    2. dlx1a/2a act downstream of ascl1a but upstream of dlx5a/dlx6a and gad1b to activate GABAergic specification
      Title: The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon.
    3. This study demonistrated that dlex2 expresssion aroud striatal and pallidal territories.
      Title: Contributions of developmental studies in the dogfish Scyliorhinus canicula to the brain anatomy of elasmobranchs: insights on the basal ganglia.
    4. embryos injected with dlx1a and dlx2a but not dlx1a MOs exhibit reduced and dysmorphic arch cartilage elements.
      Title: Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chordate embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of photoreceptor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neural crest cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pharyngeal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of amacrine cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Dlx2a
    Names
    distal-less homeobox gene 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131311.2 → NP_571386.2  homeobox protein Dlx2a

      Status: VALIDATED

      Source sequence(s)
      CU469503, DT059718
      UniProtKB/Swiss-Prot
      P50574
      UniProtKB/TrEMBL
      A0A8N7UZI8, F6NKE2
      Related
      ENSDARP00000103004.2, ENSDART00000111386.4
      Conserved Domains (2) summary
      pfam00046
      Location:130 → 183
      Homeobox; Homeobox domain
      pfam12413
      Location:32 → 107
      DLL_N; Homeobox protein distal-less-like N terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      3397407..3400729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50574.1 GenPept UniProtKB/Swiss-Prot:P50574

    Gene LinkOut

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