cyfip1 cytoplasmic FMR1 interacting protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyfip1provided by ZNC
Official Full Name: cytoplasmic FMR1 interacting protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8557
See related: Ensembl:ENSDARG00000044345 AllianceGenome:ZFIN:ZDB-GENE-030131-8557
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CY; CYFIP; fb15a06; wu:fb15a06
Summary: Predicted to enable RNA 7-methylguanosine cap binding activity; actin filament binding activity; and translation repressor activity. Acts upstream of or within with a positive effect on axon extension. Predicted to be located in cytoplasm. Predicted to be part of SCAR complex. Predicted to be active in neuron projection and synapse. Is expressed in dorsal telencephalon. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (37655213..37730508)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (37677319..37752614)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fb01c05.x1 (e-PCR)
- UniSTS:189780

AI396612 (e-PCR)
- UniSTS:206698

fc76b03.y1 (e-PCR)
- UniSTS:194468

Z793 (e-PCR)
- UniSTS:74165

fe49b03.y1 (e-PCR)
- UniSTS:196538

fb15a06.x1 (e-PCR)
- UniSTS:202941

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables translation repressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in modification of synaptic structure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in ruffle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytoplasmic FMR1-interacting protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.