vipr2 vasoactive intestinal peptide receptor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vipr2provided by ZNC
Official Full Name: vasoactive intestinal peptide receptor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-010406-4
See related: Ensembl:ENSDARG00000012353 AllianceGenome:ZFIN:ZDB-GENE-010406-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pacap; vpac2; vpac2-R
Summary: Predicted to enable G protein-coupled peptide receptor activity; peptide hormone binding activity; and vasoactive intestinal polypeptide receptor activity. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; gut; heart; integument; and pleuroperitoneal region. Orthologous to human VIPR2 (vasoactive intestinal peptide receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (27268099..27346951)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (27188940..27267792)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study found a protective effect of PACAP-38 on oxidative stress damage in zebrafish hair cells, suggesting PACAP-38 ability to prevent hair cells from apoptosis. PACAP-38 treatment decreased the cleaved caspase-3 level in the hair cells, but somewhat unexpectedly had no influence on p-38 MAPK pathway. PACAP-38 treatment also rescued H2O2-induced reduction in movement.
Title: Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Oxidative Stress in Zebrafish Hair Cells.
PACAP might play dual roles in regulating follicle growth and maturation through different receptors located in different compartments.
Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in the zebrafish ovary: evidence for potentially dual roles of PACAP in controlling final oocyte maturation.
These results suggest that, in fish, PACAP and PAC1-R may play a role in brain development.
Title: Expression analysis of PAC1-R and PACAP genes in zebrafish embryos.
zfPACAP38-2 is a potential ovarian factor that mediates gonadotropin actions in paracrine/autocrine manners, and its functional roles are likely, to some extent, related to the ovarian activin/follistatin system.
Title: Cloning, regulation of messenger ribonucleic acid expression, and function of a new isoform of pituitary adenylate cyclase-activating polypeptide in the zebrafish ovary.
The temporal and spatial expression pattern of the ghrh-pacap1 transcript suggests that these hormones may modulate patterning during development.
Title: Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables vasoactive intestinal polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasoactive intestinal polypeptide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vasoactive intestinal polypeptide receptor 2

Names: PHI-R; PHIR; VPAC2R; histidine-isoleucine receptor; pituitary adenylate cyclase-activating peptide; vasoactive intestingal polypeptide receptor type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131779.1 → NP_571854.1 vasoactive intestinal polypeptide receptor 2 precursor

See identical proteins and their annotated locations for NP_571854.1

Status: PROVISIONAL

Source sequence(s)

EU069395

UniProtKB/TrEMBL

A7UH65

Related

ENSDARP00000110404.2, ENSDART00000122639.3

Conserved Domains (2) summary

pfam00002
Location:124 → 372

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:50 → 110

HRM; Hormone receptor domain