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    ptk2ab protein tyrosine kinase 2ab [ Danio rerio (zebrafish) ]

    Gene ID: 142986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ptk2abprovided by ZNC
    Official Full Name
    protein tyrosine kinase 2abprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020114-1
    See related
    Ensembl:ENSDARG00000004672 AllianceGenome:ZFIN:ZDB-GENE-020114-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fak; ptk2; fak1a; ptk2a; ptk2.1; zgc:66114; wu:fa18c04
    Summary
    Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in regulation of convergent extension involved in gastrulation. Acts upstream of or within with a positive effect on midbrain-hindbrain boundary morphogenesis. Acts upstream of or within lens fiber cell morphogenesis and regulation of protein localization. Predicted to be located in several cellular components, including cytoskeleton; focal adhesion; and plasma membrane. Is expressed in eye; notochord; segmental plate; somite; and vertical myoseptum. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ptk2ab in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (30737278..30869732, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (30779351..30911845, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 210 member Ab Neighboring gene low density lipoprotein receptor class A domain containing 4b Neighboring gene DENN/MADD domain containing 3b Neighboring gene solute carrier family 45 member 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase. Gutzman JH, et al. Biol Open, 2018 Nov 13. PMID 30305282, Free PMC Article
    2. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. Hirth S, et al. PLoS One, 2016. PMID 26954676, Free PMC Article
    3. Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. Semina EV, et al. Dev Biol, 2006 Nov 1. PMID 16973147
    4. Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion. Woo S, et al. J Neurosci, 2009 Nov 4. PMID 19890008, Free PMC Article
    5. Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis. Crawford BD, et al. Mol Biol Cell, 2003 Aug. PMID 12925747, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data support a crucial role for miR-27 in promoting chondrogenic differentiation in the pharyngeal arches through regulation of FAK.
      Title: miR-27 regulates chondrogenesis by suppressing focal adhesion kinase during pharyngeal arch development.
    2. findings highlight an essential role of Paxillin and FAK in controlling cardiac contractility via the recruitment of Vinculin to mechano-sensitive sites in cardiomyocytes.
      Title: Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart.
    3. Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
      Title: Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish.
    4. Focal adhesion kinase (FAK) mediates regulation of growth cone adhesion in the optic tectum of zebrafish.
      Title: Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66114

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lens fiber cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect midbrain-hindbrain boundary morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect midbrain-hindbrain boundary morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of convergent extension involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    focal adhesion kinase 1
    Names
    faka
    focal adhesion kinase
    protein tyrosine kinase 2.1
    protein tyrosine kinase 2a
    NP_571871.1
    XP_005158222.1
    XP_009290686.1
    XP_068069970.1
    XP_068069971.1
    XP_068069972.1
    XP_068069973.1
    XP_068069974.1
    XP_068069975.1
    XP_068069976.1
    XP_068069977.1
    XP_068069978.1
    XP_068069979.1
    XP_068069980.1
    XP_068069981.1
    XP_068069982.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131796.1 → NP_571871.1  focal adhesion kinase 1

      See identical proteins and their annotated locations for NP_571871.1

      Status: PROVISIONAL

      Source sequence(s)
      AF348085
      UniProtKB/TrEMBL
      A0A8M2B500, Q98SN4
      Related
      ENSDARP00000042715.7, ENSDART00000042716.9
      Conserved Domains (6) summary
      cd05056
      Location:417 → 686
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:36 → 258
      B41; Band 4.1 homologues
      cd13190
      Location:254 → 358
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:143 → 248
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:914 → 1042
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:424 → 678
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      30737278..30869732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213876.1 → XP_068069977.1  focal adhesion kinase 1 isoform X9

      UniProtKB/TrEMBL
      A0A8M9PCX0
      Related
      ENSDARP00000156652.1, ENSDART00000190168.1

    2. XM_068213871.1 → XP_068069972.1  focal adhesion kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9NZ18
      Related
      ENSDARP00000155999.1, ENSDART00000190444.1

    3. XM_005158165.5 → XP_005158222.1  focal adhesion kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A8M2B4I9, A0A8M2B500
      Conserved Domains (6) summary
      cd05056
      Location:455 → 724
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:74 → 296
      B41; Band 4.1 homologues
      cd13190
      Location:292 → 396
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:181 → 286
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:952 → 1080
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:462 → 716
      Pkinase_Tyr; Protein tyrosine kinase

    4. XM_068213874.1 → XP_068069975.1  focal adhesion kinase 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PJ73

    5. XM_068213877.1 → XP_068069978.1  focal adhesion kinase 1 isoform X10

      UniProtKB/TrEMBL
      A0A8M2B4H7
      Related
      ENSDARP00000109075.3, ENSDART00000128158.4

    6. XM_068213872.1 → XP_068069973.1  focal adhesion kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PCW5

    7. XM_068213878.1 → XP_068069979.1  focal adhesion kinase 1 isoform X11

      UniProtKB/TrEMBL
      A0A8M2B527

    8. XM_068213873.1 → XP_068069974.1  focal adhesion kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9PM62

    9. XM_009292411.4 → XP_009290686.1  focal adhesion kinase 1 isoform X8

      UniProtKB/TrEMBL
      A0A2R8RR02, A0A8M2B4H7, A0A8M3B1R9
      Related
      ENSDARP00000150959.1, ENSDART00000191106.1
      Conserved Domains (6) summary
      cd05056
      Location:468 → 737
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00295
      Location:74 → 296
      B41; Band 4.1 homologues
      cd13190
      Location:292 → 396
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:181 → 286
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:965 → 1093
      Focal_AT; Focal adhesion targeting region
      pfam07714
      Location:475 → 729
      Pkinase_Tyr; Protein tyrosine kinase

    10. XM_068213875.1 → XP_068069976.1  focal adhesion kinase 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M2B4H7

    11. XM_068213869.1 → XP_068069970.1  focal adhesion kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PM54

    12. XM_068213870.1 → XP_068069971.1  focal adhesion kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PCW2
      Related
      ENSDARP00000149861.1, ENSDART00000191321.1

    13. XM_068213880.1 → XP_068069981.1  focal adhesion kinase 1 isoform X14

    14. XM_068213879.1 → XP_068069980.1  focal adhesion kinase 1 isoform X13

    15. XM_068213881.1 → XP_068069982.1  focal adhesion kinase 1 isoform X15

    Nucleotide Protein Strain
    Heading Accession and Version

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